Table 3 Effect modification of regular farm animal contact on allergic symptoms† by NPSR1 genotypes, among all PARSIFAL children
SNPs with genotype strataEver regular farm animal contactCurrent‡ regular farm animal contact
Asthma OR (95% CI)Rhinoconjunctivitis OR (95% CI)Allergic symptoms OR (95% CI)Asthma OR (95% CI)Rhinoconjunctivis OR (95% CI)Allergic symptoms OR (95% CI)
rs323917
CC (non-risk)0.87 (0.62 to 1.22)0.66 (0.46 to 0.97)0.78 (0.59 to 1.03)0.74 (0.52 to 1.04)0.66 (0.44 to 0.98)0.72 (0.54 to 0.96)
CG/GG1.04 (0.47 to 2.33)1.02 (0.45 to 2.28)1.07 (0.56 to 2.03)1.03 (0.46 to 2.28)0.90 (0.39 to 2.05)1.08 (0.57 to 2.07)
rs323922
GG/CG (non-risk)1.08 (0.76 to 1.54)0.78 (0.53 to 1.15)0.98 (0.73 to 1.31)*0.99 (0.68 to 1.42)*0.82 (0.55 to 1.23)*0.96 (0.71 to 1.30)**
CC0.67 (0.36 to 1.25)0.48 (0.24 to 0.98)0.51 (0.30 to 0.87)0.37 (0.18 to 0.75)0.31 (0.14 to 0.71)0.33 (0.18 to 0.60)
rs324377
AC/CC (non-risk)1.08 (0.75 to 1.56)0.81 (0.54 to 1.20)1.00 (0.74 to 1.35)*0.97 (0.67 to 1.41)*0.80 (0.52 to 1.21)0.95 (0.70 to 1.30)**
AA0.70 (0.39 to 1.27)0.48 (0.25 to 0.94)0.53 (0.32 to 0.87)0.43 (0.22 to 0.82)0.36 (0.17 to 0.78)0.38 (0.22 to 0.66)
SNP546333
AA/AG (non-risk)0.37 (0.17 to 0.83)*0.28 (0.10 to 0.78)0.38 (0.20 to 0.75)*0.52 (0.23 to 1.17)0.22 (0.06 to 0.76)0.46 (0.23 to 0.92)
GG1.03 (0.73 to 1.44)0.77 (0.53 to 1.11)0.89 (0.67 to 1.18)0.84 (0.59 to 1.18)0.77 (0.52 to 1.14)0.83 (0.62 to 1.10)
rs324384
CT/CC (non-risk)1.01 (0.70 to 1.47)0.74 (0.49 to 1.11)0.93 (0.68 to 1.26)0.91 (0.63 to 1.33)0.76 (0.50 to 1.17)0.90 (0.66 to 1.23)
TT0.77 (0.47 to 1.25)0.68 (0.39 to 1.16)0.66 (0.44 to 1.00)0.60 (0.36 to 1.00)0.58 (0.32 to 1.04)0.58 (0.38 to 0.90)
rs324396
CT/TT (non-risk)1.18 (0.77 to 1.79)0.62 (0.39 to 0.98)0.97 (0.68 to 1.37)0.96 (0.62 to 1.48)0.64 (0.39 to 1.06)0.90 (0.63 to 1.29)
CC0.73 (0.48 to 1.10)0.76 (0.48 to 1.21)0.68 (0.48 to 0.97)0.66 (0.43 to 1.00)0.68 (0.42 to 1.10)0.64 (0.45 to 0.92)
rs740347
GG (non-risk)1.04 (0.73 to 1.49)0.75 (0.50 to 1.11)0.93 (0.69 to 1.25)0.93 (0.64 to 1.34)0.84 (0.56 to 1.27)*0.92 (0.68 to 1.25)*
CC/CG0.64 (0.37 to 1.11)0.59 (0.32 to 1.09)0.58 (0.36 to 0.92)0.51 (0.29 to 0.92)0.35 (0.17 to 0.73)0.46 (0.28 to 0.77)
  • Odds ratios (OR) and 95% confidence intervals (CI) from a logistic regression model, adjusting for gender, heredity and study group.

  • †Doctor’s diagnosis of asthma and/or current symptoms of rhinoconjunctivitis.

  • ‡“Current” refers to exposures that have occurred during the last 12 months.

  • *p value for interaction <0.05 from a likelihood ratio (LR) test for the improvement of the regression model when including the interaction term.

  • **p value for interaction <0.005 from an LR test for the improvement of the regression model when including the interaction term.