| SNPs with genotype strata | Ever regular farm animal contact | Current‡ regular farm animal contact | ||||
| Asthma OR (95% CI) | Rhinoconjunctivitis OR (95% CI) | Allergic symptoms OR (95% CI) | Asthma OR (95% CI) | Rhinoconjunctivis OR (95% CI) | Allergic symptoms OR (95% CI) | |
| rs323917 | ||||||
| CC (non-risk) | 0.87 (0.62 to 1.22) | 0.66 (0.46 to 0.97) | 0.78 (0.59 to 1.03) | 0.74 (0.52 to 1.04) | 0.66 (0.44 to 0.98) | 0.72 (0.54 to 0.96) |
| CG/GG | 1.04 (0.47 to 2.33) | 1.02 (0.45 to 2.28) | 1.07 (0.56 to 2.03) | 1.03 (0.46 to 2.28) | 0.90 (0.39 to 2.05) | 1.08 (0.57 to 2.07) |
| rs323922 | ||||||
| GG/CG (non-risk) | 1.08 (0.76 to 1.54) | 0.78 (0.53 to 1.15) | 0.98 (0.73 to 1.31)* | 0.99 (0.68 to 1.42)* | 0.82 (0.55 to 1.23)* | 0.96 (0.71 to 1.30)** |
| CC | 0.67 (0.36 to 1.25) | 0.48 (0.24 to 0.98) | 0.51 (0.30 to 0.87) | 0.37 (0.18 to 0.75) | 0.31 (0.14 to 0.71) | 0.33 (0.18 to 0.60) |
| rs324377 | ||||||
| AC/CC (non-risk) | 1.08 (0.75 to 1.56) | 0.81 (0.54 to 1.20) | 1.00 (0.74 to 1.35)* | 0.97 (0.67 to 1.41)* | 0.80 (0.52 to 1.21) | 0.95 (0.70 to 1.30)** |
| AA | 0.70 (0.39 to 1.27) | 0.48 (0.25 to 0.94) | 0.53 (0.32 to 0.87) | 0.43 (0.22 to 0.82) | 0.36 (0.17 to 0.78) | 0.38 (0.22 to 0.66) |
| SNP546333 | ||||||
| AA/AG (non-risk) | 0.37 (0.17 to 0.83)* | 0.28 (0.10 to 0.78) | 0.38 (0.20 to 0.75)* | 0.52 (0.23 to 1.17) | 0.22 (0.06 to 0.76) | 0.46 (0.23 to 0.92) |
| GG | 1.03 (0.73 to 1.44) | 0.77 (0.53 to 1.11) | 0.89 (0.67 to 1.18) | 0.84 (0.59 to 1.18) | 0.77 (0.52 to 1.14) | 0.83 (0.62 to 1.10) |
| rs324384 | ||||||
| CT/CC (non-risk) | 1.01 (0.70 to 1.47) | 0.74 (0.49 to 1.11) | 0.93 (0.68 to 1.26) | 0.91 (0.63 to 1.33) | 0.76 (0.50 to 1.17) | 0.90 (0.66 to 1.23) |
| TT | 0.77 (0.47 to 1.25) | 0.68 (0.39 to 1.16) | 0.66 (0.44 to 1.00) | 0.60 (0.36 to 1.00) | 0.58 (0.32 to 1.04) | 0.58 (0.38 to 0.90) |
| rs324396 | ||||||
| CT/TT (non-risk) | 1.18 (0.77 to 1.79) | 0.62 (0.39 to 0.98) | 0.97 (0.68 to 1.37) | 0.96 (0.62 to 1.48) | 0.64 (0.39 to 1.06) | 0.90 (0.63 to 1.29) |
| CC | 0.73 (0.48 to 1.10) | 0.76 (0.48 to 1.21) | 0.68 (0.48 to 0.97) | 0.66 (0.43 to 1.00) | 0.68 (0.42 to 1.10) | 0.64 (0.45 to 0.92) |
| rs740347 | ||||||
| GG (non-risk) | 1.04 (0.73 to 1.49) | 0.75 (0.50 to 1.11) | 0.93 (0.69 to 1.25) | 0.93 (0.64 to 1.34) | 0.84 (0.56 to 1.27)* | 0.92 (0.68 to 1.25)* |
| CC/CG | 0.64 (0.37 to 1.11) | 0.59 (0.32 to 1.09) | 0.58 (0.36 to 0.92) | 0.51 (0.29 to 0.92) | 0.35 (0.17 to 0.73) | 0.46 (0.28 to 0.77) |
Odds ratios (OR) and 95% confidence intervals (CI) from a logistic regression model, adjusting for gender, heredity and study group.
†Doctor’s diagnosis of asthma and/or current symptoms of rhinoconjunctivitis.
‡“Current” refers to exposures that have occurred during the last 12 months.
*p value for interaction <0.05 from a likelihood ratio (LR) test for the improvement of the regression model when including the interaction term.
**p value for interaction <0.005 from an LR test for the improvement of the regression model when including the interaction term.