Variation | MAF | Model | ||||||
Genotypic | Allelic (trend) | |||||||
Counts | χ2 | p Value | Counts | χ2 | p Value | |||
5′-11A→G/c.20T→C | 0.29 | vCJD | 11/40/56 | 3.655 | 0.16 | 62/152 | 1.43 | 0.23 |
0.28 | sCJD | 30/172/213 | 7.135 | 0.028 | 232/598 | 6.8 | 0.009 | |
0.33 | Control | 81/405/375 | – | – | 567/1155 | – | – | |
c.136_137insG | 0.01 | vCJD | 0/2/105 | NA | NA | 2/212 | 16.1 | 0.01† |
0 | sCJD | 0/0/415 | NA | NA | 0/830 | NA | NA | |
0 | Control | 0/0/861 | – | – | 0/1722 | – | – |
NA, not applicable; sCJD, sporadic Creutzfeldt–Jakob disease; vCJD, variant Creutzfeldt–Jakob disease.
†Denotes Fisher Exact test applied because cell counts were small. Genotypic counts and allelic counts are displayed AA/AB/BB and A/B respectively, where A = 5′-11G (c.20C) or c.136_137insG.
Bold type denotes significance.