Table 4 Sliding window haplotype association analysis:
(1) rs729302; (2) rs4728142; (3) rs3757385; (4) CGGGG indel; (5) rs2004640; (6) rs3807306; (7) rs10954213; (8) rs11770589; (9) rs2280714; (10) rs12539741SpainSwedenFinlandCombined p valueCombined corrected p value‡
(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)
FaffFunaffp ValueFaffFunaffp ValueFobs*Obs-Exp†p Value
AAGinT0.490.440.00360.440.410.0190.41+0.0100.0000810.0032
CGTdelG0.170.180.550.170.180.610.200.420.68NS
AGTdelG0.130.170.00210.150.150.600.14+0.470.021NS
AGinTT0.510.460.00340.470.440.0190.43+0.0280.000180.0070
GTdelGG0.280.340.00160.280.290.490.260.510.016NS
GGdelGG0.100.110.280.120.130.200.100.290.22NS
GinTTA0.530.480.0140.490.450.00610.45+0.0120.000120.0046
TdelGGG0.270.320.00180.280.290.530.250.540.019NS
GdelGGA0.100.110.290.120.130.280.110.790.48NS
inTTAA0.420.390.160.340.320.180.30+0.0680.052NS
delGGGG0.270.320.00180.280.300.260.250.520.011NS
insTTAG0.110.090.0680.150.130.0680.15+0.240.034NS
TTAAT0.440.410.130.350.330.110.31+0.0440.022NS
GGGGC0.270.320.00260.280.290.350.250.420.015NS
GGAAT0.110.130.220.130.140.350.130.560.39NS
TAATC0.460.420.0760.390.370.190.39+0.0160.010NS
GGGCC0.270.320.00280.280.290.380.250.440.018NS
GAATC0.110.130.250.130.140.400.130.590.46NS
  • *Haplotype frequency in Finnish trios. †Difference between observed and expected transmissions of the associated allele; + denotes increased and – denotes decreased transmission to affected offspring. ‡39 haplotypes were tested and a conservative Bonferroni correction factor of 39 was applied. The three highest frequency haplotypes in each window are shown. p Values are indicated in bold.