Table 3 Combined association analysis of IRF5 polymorphisms with multiple sclerosis in three cohorts

Polymorphism	Spanish c/c*	Swedish c/c*	Finnish trios	Combined p value
Polymorphism	p Value	p Value	p Value	Combined p value
rs729302	0.22	0.29	0.047	0.07
rs4728142	0.0029	0.020	0.035	0.0002
rs3757385	0.0052	0.43	0.53	0.04
CGGGG indel	0.011	0.0093	0.056	0.0005
rs2004640	0.0011	0.082	0.54	0.003
rs3807306	0.0037	0.049	0.012	0.0002
rs10954213	0.031	0.15	0.010	0.003
rs11770589	0.29	0.49	0.070	0.16
rs2280714	0.0030	0.43	0.30	0.02
rs12539741	0.074	0.10	0.74	0.11

*c/c denotes case–control; p values below 0.05 are indicated in bold.