Table 1 Association analysis of IRF5 polymorphisms with multiple sclerosis in Spanish and Swedish case–control cohorts

Polymorphism	Position (bp)	Location	Major/minor allele*	Risk allele	Risk allele frequency				Risk allele frequency
					Spanish cohort				Swedish cohort
					Cases (n = 650)	Controls (n = 797)	p Value	OR (95% CI)	Cases (n = 1084)	Controls (n = 1182)	p Value	OR (95% CI)
rs729302	128356196	Promoter	A/C	A	0.7	0.68	0.22	1.11 (0.94 to 1.30)	0.67	0.66	0.29	1.07 (0.94 to 1.21)
rs4728142	128361203	Promoter	G/A	A	0.52	0.46	0.0029	1.25 (1.08 to 1.45)	0.48	0.44	0.02	1.15 (1.02 to 1.29)
rs3757385	128364540	Promoter	G/T	G	0.7	0.65	0.0052	1.25 (1.07 to 1.47)	0.67	0.66	0.43	1.05 (0.93 to 1.19)
CGGGG indel	128365152	Promoter	del/in	In	0.53	0.48	0.011	1.22 (1.05 to 1.41)	0.49	0.45	0.0093	1.17 (1.04 to 1.32)
rs2004640	128365537	First intron	T/G	T	0.59	0.53	0.0011	1.28 (1.11 to 1.49)	0.55	0.52	0.082	1.11 (0.99 to 1.25)
rs3807306	128367916	First intron	T/G	T	0.57	0.52	0.0037	1.25 (1.08 to 1.45)	0.54	0.51	0.049	1.12 (1.00 to 1.26)
rs10954213	128376663	3′ UTR	A/G	A	0.69	0.65	0.031	1.19 (1.02 to 1.39)	0.67	0.64	0.15	1.10 (0.97 to 1.24)
rs11770589	128376724	3′ UTR	A/G	A	0.57	0.55	0.29	1.08 (0.93 to 1.26)	0.51	0.5	0.49	1.04 (0.93 to 1.17)
rs2280714	128381961	Downstream	T/C	T	0.73	0.68	0.003	1.28 (1.09 to 1.51)	0.71	0.7	0.43	1.05 (0.93 to 1.20)
rs12539741	128384041	Downstream	C/T	T	0.11	0.09	0.074	1.27 (0.98 to 1.65)	0.15	0.14	0.10	1.15 (0.97 to 1.36)

*Major and minor alleles in unaffected subjects.
p Values below 0.05 are indicated in bold.