Table 6 Heritability of IDF and ATP metabolic syndrome definitions and its log normal transformed individual components in Erasmus Rucphen Family population
Parameterh2 (%)*SEMp Value†S (%)‡SEMp Value†
n2488
IDF10.65.30.019.056.20.07
ATPIII13.26.00.0715.897.4<0.05
ln WC37.84.6<10−65.63.4<0.05
ln FPG22.74.7<10−69.63.6<0.01
ln SBP25.44.3<10−67.83.3<0.01
ln DBP21.94.6<10−62.73.30.20
ln HDL-C42.94.1<10−60.0
ln TG28.34.4<10−64.13.30.10
  • ATPIII, National Cholesterol Education program Adult Panel III; DBP, diastolic blood pressure; FPG, fasting plasma glucose; HDL-C, high density lipoprotein cholesterol; IDF, International Diabetes Federation; SBP, systolic blood pressure; TG, triglyceride; WC, waist circumference.

  • *Heritability based on polygenic household model with consideration of the sibship effect (S), covariates: gender, age and inbreeding coefficient. †p values were derived using the likelihood ratio test. ‡S (%) sibship effect.