| (A) | * |
| Human | TFGQKPVKFQ |
| Mouse | TFGQKPVKFQ |
| Chick | TFGQKPVKFQ |
| Xenopus | TFGQKPVKFQ |
| Drosophila | TYGDKPVAFQ |
| Bovine | TFGQKPVKFQ |
| Chimp | TFGQKPVKFQ |
| Zebrafish | ------------------- |
| (B) | * |
| Human | DMSEKENSPEKF |
| Mouse | DMSEKENSPEKF |
| Chick | DMSEKENSPEKF |
| Xenopus | DMSEKENSPEKF |
| Drosophila | DMSEKNNNPEEF |
| Bovine | DMSEKENSPEKF |
| Chimp | DMSEKENSPEKF |
| Zebrafish | DMSEKENSPESF |
| (C) | * |
| Human | PLLETLTDAEMEKK |
| Mouse | PLLETLTDAEMEKK |
| Chick | PLLETLTDAEMEKK |
| Xenopus | PLLETLTDAEMEKK |
| Drosophila | PFLETLTDAEMEKK |
| Bovine | PLLETLTDAEMEKK |
| Chimp | PLLETLTDAEMEKK |
| Zebrafish | PLLETLTDAEMEKK |
Segments shown include the amino acid residues at which missense mutations occurred (*) (A) P14H (B) N288K (C) D369V.