Logistic regression for prediction of carrier status based on family history in 191 families with at least one affected individual tested
| Family characteristics* | OR | p Value (95% CI) |
|---|---|---|
| Br, breast; Ca, cancer; Ov, ovarian. | ||
| *Female breast and ovarian cancer cases were at most third-degree relatives of the proband, whereas the presence of male patients with breast cancer was considered at any degree from the proband; 10 cases of ductal carcinoma in situ included. | ||
| BRCA1+ v no mutation detected | ||
| 0–1 cases Br Ca <50 years | 1 (Ref) | |
| 2–3 cases Br Ca <50years | 4.7 | 0.12 (0.7 to 32.8) |
| ⩾4 cases Br Ca <50 years | 46.3 | 0.001 (4.8 to 443) |
| 0–1 cases Br Ca ⩾50 years | 1 (Ref) | |
| 2–3 cases Br Ca ⩾50 years | 0.2 | 0.022 (0.04 to 0.8) |
| ⩾4 cases Br Ca ⩾50 years | 0.1 | 0.10 (0.01 to 1.5) |
| No Ov Ca | 1 (Ref) | |
| 1 case Ov Ca | 10.6 | 0.005 (2.0 to 54.7) |
| ⩾2 cases Ov Ca | 284 | <0.001 (33 to 2466) |
| ⩾1 male Br Ca v none | 24.8 | 0.076 (0.7 to 868) |
| ⩾1 bilateral Br Ca v none | 7.5 | 0.014 (1.5 to 37) |
| BRCA2+ v no mutation detected | ||
| 0–1 cases Br Ca <50 years | 1 (Ref) | |
| 2–3 cases Br Ca <50 years | 1.7 | 0.39 (0.5 to 5.7) |
| ⩾4 cases Br Ca <50 years | 5.9 | 0.010 (1.5 to 23) |
| 0–1 cases Br Ca ⩾50 years | 1 (Ref) | |
| 2–3 cases Br Ca ⩾50 years | 0.5 | 0.22 (0.1 to 41.6) |
| ⩾4 cases Br Ca ⩾50 years | 0.9 | 0.94 (0.2 to 53.6) |
| No Ov Ca | 1 (Ref) | |
| 1 case Ov Ca | 1.6 | 0.48 (0.4 to 4.7) |
| ⩾2 cases Ov Ca | 17.0 | <0.001 (3.7 to 78) |
| ⩾1 male Br Ca v none | 13.7 | 0.004 (2.3 to 80) |
| ⩾1 bilateral Br Ca v none | 3.7 | 0.019 (1.2 to 11) |
| BRCA1/BRCA2+ v no mutation detected | ||
| 0–1 cases Br Ca <50 years | 1 (Ref) | |
| 2–3 cases Br Ca <50 years | 2.4 | 0.12 (0.8 to 7.2) |
| ⩾4 cases Br Ca <50 years | 10.4 | <0.001 (3.1 to 36) |
| 0–1 cases Br Ca ⩾50 years | 1 (Ref) | |
| 2–3 cases Br Ca ⩾50 years | 0.4 | 0.047 (0.13 to 0.99) |
| ⩾4 cases Br Ca ⩾50 years | 0.6 | 0.37 (0.16 to 2.10) |
| No Ov Ca | 1 (Ref) | |
| 1 case Ov Ca | 2.8 | 0.059 (0.9 to 67.9) |
| ⩾2 cases Ov Ca | 51 | <0.001 (13.5 to 195) |
| ⩾1 male Br Ca v none | 14.8 | 0.004 (2.4 to 91) |
| ⩾1 bilateral Br Ca v none | 5.2 | 0.001 (1.9 to 14.1) |