Predictors of a CDKN2A mutation from simultaneous evaluation of the four factors (MedAge, multiple primary melanomas, pancreatic cancer, no of cutaneous malignant melanomas/family) across the groups (Total, Australia, North America and Europe)
| Variables in final model | Level of variable [OR (95% CI)] | |||
|---|---|---|---|---|
| Total | Australia | North America | Europe | |
| CMM, cutaneous malignant melanoma; #CMM/family, number of patients with CMM per family; MPM, multiple primary melanomas; PC, pancreatic cancer; dash indicates that the variable did not appear in the final model. | ||||
| Only the levels of the features and corresponding OR and 95% CI that were significantly associated with the risk of mutation are shown for each group (final model). | ||||
| MedAge (years) | ⩽50 | ⩽40 | ⩽40 | ⩽50 |
| [7.42 (3.44 to 16.02)] | [19.62 (5.31 to 72.46)] | [4.04 (1.06 to 15.32)] | [5.15 (1.74 to 15.21)] | |
| MPM | ⩾1 | ⩾2 | ⩾1 | ⩾1 |
| [5.73 (3.40 to 9.68)] | [6.23 (2.20 to 17.60)] | [5.30 (2.42 to 11.65)] | [6.24 (2.72 to 14.32)] | |
| PC | ⩾1 | — | — | ⩾1 |
| [7.54 (3.42 to 16.67)] | [8.21 (2.39 to 28.24)] | |||
| #CMM/family | — | ⩾6 | — | ⩾4 |
| [6.65 (1.76 to 25.06)] | [2.44 (1.05 to 5.64)] | |||
| Number of families | 385 | 162 | 65 | 157 |