Table 1 Background variables of unaffected high-risk subjects consenting to a study informing about predictive genetic testing for hereditary non-polyposis colon cancer comparing the direct-contact and family-mediated approaches

	DCA			All	p Value*	FMA			All	p Value*	p Value‡
	Consented	Refused	No response	All	p Value*	Consented	Refused	No response	All	p Value*	p Value‡
n	147	28	111	286		401	11	34	446
%	51	10	39	100		90	2	8	100
Gender (%)
Male	52	8	40	100	0.40	87	2	11	100	0.06	0.12
Female	50	12	38	100		93	2	5	100
Marital status (%)
Married/cohabiting	59	11	31	100	<0.01	94	2	4	100	<0.001	0.37
Living alone	41	9	50	100		82	3	15	100
Parenthood (%)
Children	54	9	37	100	0.40	88	2	10	100	0.37	0.82
No children	45	11	44	100		91	3	6	100
Mean (SD) age	51.6 (12.5)	62.0 (14.4)	54.1 (13.8)	53.6 (13.5)	0.001†	42.9 (14.0)	48.6 (16.9)	43.2 (13.0)	43.0 (14.0)	0.42†	0.55§

DCA, direct-contact approach, FMA, family-mediated approach.
*p Value for χ² test between groups.
†p Value for one-way analysis of variance between groups.
‡Test for interaction term between study and consenting variable from logistic regression.
§Interaction term between study and consenting variable from two-way analysis of variance.