Table 1 Study criteria of subject’s inclusion for E-cadherin mutation analysis.
Criteria for inclusionCases, nAge (years), median (range)
Proband with documented invasive lobular or mixed ductal and lobular breast cancers tested negative for germline BRCA1 and BRCA2 mutations, and:
Family history with two or more cases of breast cancer in first or second degree relatives in the maternal or paternal lineage, including third degree relatives in the paternal lineage, or1946 (36 to 66)
Proband diagnosed with lobular or mixed breast cancer before 45 years of age independent of family history440.5 (36 to 42)