Severity classification of the phenotype
| Prenatal growth | Postnatal growth* | Skull growth | Limbs | Face | Adaptive functioning | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| *CdLS standard growth curves were used.41 | ||||||||||
| 1 = >2500 g | 1 = >P75 | 1 = OFC>−2SD | 1 = no reduction defect | 1 = possible CdLS | 1 = normal/borderline | |||||
| 2 = 1500–2500 g | 2 = P25−P75 | 2 = −2SD>OFC>−4SD | 2 = partial reduction defects (absence of 1 or 2 fingers) | 2 = mild type | 2 = mild/moderately impaired | |||||
| 3 = <1500 g | 3 = <P25 | 3 = OFC<−4SD | 3 = severe reduction defects (absence of 3 of more fingers or complicated oligo/polydactyly) | 3 = classic type | 3 = severely/profoundly impaired | |||||