Results of regression analysis shown separately for the exploratory case-control study and the combined data set
| Sample | Model | Parameter | Estimate | Standard error | Wald χ2 (df = 1) | p value |
|---|---|---|---|---|---|---|
| Statistical parameters are presented for a reduced and a saturated model in both studies. | ||||||
| Exploratory case | Reduced model | Intercept | 0.06 | 0.08 | 0.50 | 0.48 |
| control study | rhHCR | −0.60 | 0.08 | 60.69 | 6.70×10−15 | |
| rhPTPN22 | −0.22 | 0.08 | 8.02 | 0.0046 | ||
| Saturated model | Intercept | 0.06 | 0.08 | 0.53 | 0.4660 | |
| rhHCR | −0.61 | 0.08 | 59.10 | 1.50×10−14 | ||
| rhPTPN22 | −0.22 | 0.08 | 8.05 | 0.0046 | ||
| rhHCR*rhPTPN22 | 0.04 | 0.08 | 0.31 | 0.58 | ||
| Combined case | Reduced model | Intercept | −0.17 | 0.05 | 9.48 | 0.0021 |
| control studies | rhHCR | −0.66 | 0.05 | 157.93 | 3.21×10−36 | |
| rhPTPN22 | −0.17 | 0.05 | 10.3511 | 0.0013 | ||
| Saturated model | Intercept | −0.16 | 0.05 | 9.37 | 0.0022 | |
| rhHCR | −0.66 | 0.05 | 151.93 | 6.55×10−35 | ||
| rhPTPN22 | −0.17 | 0.05 | 10.21 | 0.0014 | ||
| rhHCR*rhPTPN22 | 0.02 | 0.05 | 0.12 | 0.73 | ||