Frequencies of associated haplotypes within defined LD blocks and statistical parameters
| Block-haplotype | Allele combination | Frequency | Statistical parameters | |||||
|---|---|---|---|---|---|---|---|---|
| Controls | Psoriasis vulgaris patients | χ2 (df = 1) | p value | pc value | OR (95% CI) | |||
| A: exploratory case-control study (375 cases and 376 controls); B: combined study cohorts (793 cases and 937 controls). CI, confidence interval; NS, not significant; OR, odds ratio; Pc, corrected p value. | ||||||||
| A | A-3 | A G G C A A A A | 0.183 | 0.232 | 5.362 | 0.021 | NS | 1.35 (1.05 to 1.74) |
| B-3 | A C A G | 0.203 | 0.265 | 8.216 | 0.004 | 0.02 | 1.42 (1.12 to 1.81) | |
| B-4 | A C A A | 0.137 | 0.095 | 6.657 | 0.010 | NS | ||
| C-3 | C G G C | 0.209 | 0.169 | NS | NS | – | ||
| C-4 | C A G G | 0.189 | 0.243 | 6.433 | 0.011 | 0.044 | 1.38 (1.07 to 1.76) | |
| B | B-3 | A C A G | 0.222 | 0.264 | 8.495 | 0.004 | 0.02 | 1.26 (1.08 to 1.47) |
| B-4 | A C A A | 0.137 | 0.100 | 11.435 | 0.00072 | 0.0036 | ||
| C-3 | C G G C | 0.206 | 0.162 | 10.505 | 0.001 | 0.004 | ||
| C-4 | C A G G | 0.199 | 0.239 | 7.733 | 0.005 | 0.02 | 1.26 (1.07 to 1.48) | |