Observations of missense substitutions in BRCA1 in individuals who also carry a clearly deleterious BRCA1 mutation
| Count* | Polymorphism† | Unclassified | Deleterious† | Total |
|---|---|---|---|---|
| *Each row is a co-occurrence count bin. Thus the first row gives the number of missense substitutions that were not observed to co-occur with a clearly deleterious mutation. The third row gives the number of missense substitutions that were observed to co-occur with exactly two clearly deleterious mutations, or (in parentheses) exactly two different deleterious mutations. | ||||
| †Includes missense substitutions recently classified in either Goldgar et al7 or Phelan et al.26 | ||||
| 0 | 1 (1) | 351 (351) | 28 (28) | 380 (380) |
| 1 | 0 (0) | 39 (46) | 0 (0) | 39 (46) |
| 2 | 1 (1) | 4 (3) | 0 (0) | 5 (4) |
| 3 | 1 (2) | 6 (7) | 0 (0) | 7 (9) |
| 4–5 | 2 (1) | 2 (0) | 0 (0) | 4 (1) |
| 6–10 | 1 (1) | 2 (1) | 0 (0) | 3 (2) |
| 11–100 | 3 (4) | 4 (0) | 0 (0) | 7 (4) |
| >100 | 7 (6) | 0 (0) | 0 (0) | 7 (6) |
| 16 (16) | 408 (408) | 28 (28) | 452 (452) | |