Adjusted* mean annual decline in FEV1 (ml/year) and FEV1/FVC (U/year) in genotypes of the HO1 gene promoter
| HO1 genotype | p for association | p for trend | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L/L+L/M+L/S | M/M | M/S | S/S | |||||||||
| Data are means (95% CI). *Multiple linear regression including centre, sex, and ECRHS I data for age, smoking status, BMI, and spirometry (that is, baseline FEV1 for decline in FEV1 and baseline FEV1/FVC for decline in FEV1/FVC) | ||||||||||||
| Decline in FEV1, ml/year | −33.3 (−39.6 to −27.3) | −31.5 (−35.6 to −27.5) | −33.4 (−37.0 to −29.9) | −30.8 (−36.5 to −25.1) | 0.80 | 0.66 | ||||||
| Decline in FEV1/FVC, U/year | −2.56 (−3.67 to −1.46) | −1.51 (−2.26 to −0.77) | −1.80 (−2.45 to −1.15) | −0.56 (−1.61 to −0.46) | 0.058 | 0.014 | ||||||