Table 4

 Odds ratio for coronary heart disease by mutation type in men and women combined, unadjusted and adjusted for risk factors

CHD+ve/CHD−ve(% CHD+ve)OR* (95% CI)OR† (95% CI)OR‡ (95% CI)OR§ (95% CI)
*Model 1 adjusted for age, sex, smoking (never v ex and current) and systolic blood pressure at recruitment.
†Model 2 plus HDL at recruitment.
‡Model 3 plus LDL at recruitment.
δModel 1 plus recorded pretreatment. Total cholesterol or group average value if data not recorded.
¶Fisher exact test.
None55/101 (35.2)1.001.001.001.00
LDLR (any)91/145 (38.6)1.84 (1.10 to 3.06) p = 0.021.81 (1.08 to 3.01) p = 0.022.23 (1.30 to 3.83) p = 0.0041.70 (1.01 to 2.86) p = 0.05
APOB (R3500Q)6/4 (60)3.40 (0.71 to 16.36) p = 0.133.44 (0.71 to 16.8) p = 0.134.06 (0.84 to19.68) p = 0.083.76 (0.76 to 18.76) p = 0.11
PCSK9 (D374Y)6/1 (85.7)19.96 (1.88 to 211.55) p = 0.0116.22 (1.56 to 168.3) p = 0.0247.73 (3.79 to 601) p = 0.00314.74 (1.35 to 161) p = 0.03
p Valuep = 0.03¶p = 0.003p = 0.006p = 0.001p = 0.01