Table 2

 History of cancer in 30 kindreds of 41 probands with the R337H TP53 mutation

Kindred/syndromeNo interviewedNo of R337H carrier siblingsOther cancers in the lineage carrying the R337H TP53 mutation
Age ⩽45 yearsAge >45 years
First degreeSecond degree*First degreeSecond degree*
*Mutation status not known.
†R337H carriers (the only cases with other types of tumours tested for R337H): LFL, Li-Fraumeni like syndrome as defined by Birch et al, 1994.5
‡Assumed genotype.
y, years.
191
2/LFL152Liver (41 y), brain (44 y), prostate (45 y)Stomach (54 y)
3121Stomach (62 y)
4101Breast (90 y)
560Brain (53 y)
660Oesophagus (52 y)
781Bone (46 y)†
860Oesophagus (57 y)
9/LFL101Breast (36 y)Breast (49 y)
1070
11121Lung (57 y)
12161Brain (42 y)
13121Larynx (41 y)Axilla (52 y)
1461
15121Prostate (54 y)
1680
17100
18/LFL141Breast (36 y)†Stomach (56 y)
19120
2050Throat (62 y)
2160
22121Stomach (61 y), liver (63 y)
23/LFL82Liver (45 y)Uterus (61 y), prostate (64 y), lung (48 y)
2453
25/LFL2013Brain (7 y)†Unknown abdominal cancer (59 y)‡
26/LFL121Breast (39 y)Larynx (50 y)
2790
28/LFL61Stomach (41 y)
29141
30131
Total: 30 301 36 2 9 2 18