Characteristics of 30 kindreds from southern Brazil with one (n = 22) or multiple (n = 8) cases of adrenocortical tumour with the R337H TP53 mutation
| Kindred | Probands; sex and age (y) | Carrier parent | Total No tested | R337H positive relatives | Not tested | R337H positive/ probands | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ⩽15y | >15 y | ||||||||||||
| *One proband and her parents from this kindred were not available for genotyping. | |||||||||||||
| B, boy; F, father; G, girl; M, mother; NT, not tested; y, years. | |||||||||||||
| 1 | G/3.7 | M | 1 7 | 2 | 4 | 6 | 7/1 | ||||||
| 2 | G/1.7 | F | 34 | 3 | 7 | 14 | 11/1 | ||||||
| 3 | G/0.8 | M | 11 | 1 | 2 | 7 | 4/1 | ||||||
| 4 | G/3.1 | M | 30 | 3 | 4 | 2 | 8/1 | ||||||
| 5 | G/1.8 | F | 9 | 0 | 2 | 8 | 3/1 | ||||||
| 6 | G/1.2 | M | 9 | 0 | 2 | 6 | 3/1 | ||||||
| 7 | G/1.7 | M | 31 | 2 | 3 | 21 | 6/1 | ||||||
| 8 | G/2.1 | F | 15 | 0 | 2 | 9 | 3/1 | ||||||
| 9 | G/4.9 | M | 21 | 2 | 5 | 1 | 8/1 | ||||||
| 10 | B/1.0 | M | 13 | 0 | 3 | 18 | 4/1 | ||||||
| 11 | B/9.7 | F | 20 | 3 | 6 | 15 | 10/1 | ||||||
| 12 | G/2.7 | M | 42 | 3 | 10 | 4 | 14/1 | ||||||
| 13 | B/7.1 | F | 29 | 5 | 4 | 0 | 10/1 | ||||||
| 14 | G/2.9 | F | 15 | 1 | 2 | 4 | 4/1 | ||||||
| 15 | B/2.8 | M | 23 | 5 | 4 | 10 | 10/1 | ||||||
| 16 | G/1.4 | F | 14 | 0 | 4 | 14 | 5/1 | ||||||
| 17 | B/2.1 | F | 23 | 1 | 5 | 2 | 7/1 | ||||||
| 18 | G/1.7 | M | 35 | 3 | 8 | 17 | 12/1 | ||||||
| 19 | G/1.7 | F | 21 | 4 | 4 | 21 | 9/1 | ||||||
| 20 | G/2.2 | F | 14 | NT | 1 | 14 | 2/1 | ||||||
| 21 | G/2.0 | F | 10 | NT | 2 | 20 | 3/1 | ||||||
| 22 | G/0.7 | M | 34 | 6 | 3 | 13 | 10/1 | ||||||
| Total | 17G/5B | 11M/11F | 467 | 44 | 87 | 226 | 153/22 | ||||||
| 23 | B,B/1.5;2.0 | F/M | 31 | 2 | 4 | 3 | 8/2 | ||||||
| 24 | B,G/5.0;1.8 | M | 14 | 0 | 4 | 3 | 6/2 | ||||||
| 25* | G,G,G,G,B/4.0;3.5;4.7;1.0;0.9 | F/F/M/M | 73 | 5 | 17 | 15 | 26/4 | ||||||
| 26 | G,G/4.2;5.7 | F/F | 19 | 3 | 6 | 1 | 12/2 | ||||||
| 27 | G,G/1.7;4.8 | M | 15 | 1 | 4 | 0 | 7/2 | ||||||
| 28 | G,G/5.0;9.0 | M | 17 | 1 | 2 | 7 | 5/2 | ||||||
| 29 | G,G/2.0;3.0 | M/M | 32 | 3 | 8 | 11 | 13/2 | ||||||
| 30 | G,G/1.0;10.8 | M/M | 27 | 2 | 6 | 15 | 10/2 | ||||||
| Total | 14G/4B | 10M/5F | 228 | 17 | 52 | 55 | 87/18 | ||||||