Locus† | Genetic model | GRR2/GRR1 for power of 0.80 | GRR2/GRR1 for power of 0.95 | ||||
---|---|---|---|---|---|---|---|
TDT | PDT | FBAT | TDT | PDT | FBAT | ||
*GRRs needed to achieve power of 0.80 and 0.95 when testing for association of the three-locus RUNX1 and RAPTOR haplotypes are essentially identical to the GRRs of their constituent SNPs. | |||||||
†For each locus, power was tested for the allele listed in table 1. | |||||||
‡Power of 0.80 or 0.95 is not attainable. For both single SNPs and the three-locus haplotype, power at a GRR2 ( = GRR1) of 2 and 5 is 0.18 and 0.42 for the TDT, 0.22 and 0.47 for the PDT, and 0.24 and 0.52 for the FBAT. | |||||||
GRR1, genotype relative risk for test allele heterozygotes; GRR2, genotype relative risk for test allele homozygotes | |||||||
RUNX1 | Dominant | 1.69/1.69 | 1.61/1.61 | 1.52/1.52 | 2.00/2.00 | 1.92/1.92 | 1.75/1.75 |
Additive | 1.69/1.35 | 1.62/1.31 | 1.53/1.27 | 1.96/1.48 | 1.87/1.44 | 1.73/1.37 | |
Multiplicative | 1.69/1.30 | 1.62/1.27 | 1.52/1.23 | 1.96/1.40 | 1.86/1.36 | 1.72/1.31 | |
Recessive | 1.69/– | 1.63/– | 1.53/– | 1.93/– | 1.84/– | 1.70/– | |
RAPTOR | Dominant | –‡ | –‡ | –‡ | –‡ | –‡ | –‡ |
Additive | 2.09/1.54 | 1.99/1.50 | 1.81/1.41 | 2.76/1.88 | 2.59/1.80 | 2.28/1.64 | |
Multiplicative | 1.92/1.38 | 1.84/.1.36 | 1.71/1.31 | 2.33/1.53 | 2.23/1.49 | 2.01/1.42 | |
Recessive | 1.50/– | 1.47/– | 1.40/– | 1.69/– | 1.65/– | 1.55/– |