Frequencies of progression associated genotypes in patients with slow or more rapidly progressing fibrosis
| Gene | Progression associated genotype | Rate of fibrosis progression | p | Odds ratio (95% CI) | Adjusted p† | Adjusted odds ratio† (95% CI) | |
|---|---|---|---|---|---|---|---|
| Slow, n (%)* | Rapid, n (%)* | ||||||
| *Row percentages; †variables considered in the analysis included age at infection, gender, viral genotype, and BMI. | |||||||
| 95% CI, 95% confidence interval. | |||||||
| HFE | Yes (C282Y or H63D) | 19 (35.8) | 34 (64.2) | 0.122 | 1.8 (0.9 to 3.6) | 0.004 | 4.5 (1.6 to 12.2) |
| No | 46 (49.5) | 47 (50.5) | 1.0 (ref) | 1.0 (ref) | |||
| MTP | Yes (TT or GG) | 36 (36.0) | 64 (64.0) | 0.008 | 2.7 (1.3 to 5.4) | 0.005 | 4.1 (1.5 to 10.9) |
| No | 28 (59.6) | 19 (40.4) | 1.0 (ref) | 1.0 (ref) | |||
| APOE | Yes (no ε4) | 41 (40.6) | 60 (59.4) | 0.213 | 1.6 (0.8 to 3.3) | 0.017 | 3.6 (1.3 to 10.1) |
| No | 24 (52.2) | 22 (47.8) | 1.0 (ref) | 1.0 (ref) | |||
| CCR5 | Yes (wild type) AV) | 49 (41.2) | 70 (58.8) | 0.100 | 2.1 (0.9 to 4.7) | 0.044 | 3.3 (1.1 to 10.1) |
| No | 17 (58.6) | 12 (41.4) | 1.0 (ref) | 1.0 (ref) | |||
| SOD2 | Yes (TT or TC) | 37 (36.6) | 64 (63.4) | 0.016 | 2.5 (1.2 to 5.3) | 0.044 | 2.8 (1.03 to 7.4) |
| No | 25 (59.5) | 17 (40.5) | 1.0 (ref) | 1.0 (ref) | |||
| CTLA4 | Yes (AA or GG) | 23 (33.3) | 46 (66.7) | 0.029 | 2.3 (1.2 to 4.5) | 0.101 | 2.1 (0.9 to 5.2) |
| No | 40 (52.6) | 36 (47.4) | 1.0 (ref) | 1.0 (ref) | |||