Summary of current weight of evidence supporting several of the more promising genes implicated in the pathogenesis of schizophrenia and/or bipolar disorder
| Gene/locus | Chromosomal location | Evidence in schizophrenia | Evidence in bipolar disorder |
|---|---|---|---|
| More + symbols indicate greater evidence. The scale is relative. | |||
| Dysbindin | 6p22 | + + + + + | |
| Neuregulin 1 | 8p12 | + + + + | + |
| DISC 1 | 1q42 | + + + | + |
| RGS4 | 1q23 | + + | |
| COMT | 22q11 | + | + |
| DAOA(G72)/G30 | 13q33 | + + | + + |
| BDNF | 11p13 | + + | |
| DAO | 12q23 | + + | |