Table 2

Nucleotide substitutions, resulting amino acids, and number of carriers of the variants identified in PGC-1β among 61 overweight or obese white patients with type 2 diabetes

Nucleotide substitution	Nucleotide location (AY188947/AY188948)	Amino acid (PGC-1β1a and -1b)	Nucleotide location (AY188949/AY188950)	Amino acid (PGC-1β2a and -2b)	Intronic/UTR location	No. of patients
*Variant identified only in PGC-1β isoforms 2a and 2b; §variant identified only in isoforms 1a and 2a.
C→T*					−97 (5′)	23
CTT→CTC	168	Leu42Leu	343	Leu21Leu		20
C→T					IVS2-8	3
C→T					IVS2-4	4
TTC→TTT	381	Phe113Phe	556	Phe92Phe		20
CCC→CCG	450	Pro136Pro	625	Pro115Pro		1
A→G					IVS3+23	1
G→A					IVS4+43	1
GCT→CCT	649	Ala203Pro	824	Ala182Pro		8
CGG→CAG	836	Arg265Gln	1011	Arg244Gln		5
GTT→ATT	877	Val279Ile	1052	Val258Ile		8
CGC→AGC	916	Arg292Ser	1091	Arg271Ser		3
CGG→CGT	1020	Arg326Arg	1195	Arg305Arg		2
CCG→CCA	1206	Pro388Pro	1381	Pro367Pro		21
G→A					IVS6+24	8
T→G					IVS6+73	23
GGT→GGC	2280	Gly746Gly	2455	Gly725Gly		3
GCC→GCT	2328	Ala762Ala	2503	Ala741Ala		3
C→G					IVS9-31	3
C→T§					IVS11-29	2