HFE genotypes among the neonate population (all ethnic groups)
| Genotype | Observed (n = 7038) | Expected | p | |||
|---|---|---|---|---|---|---|
| Results are n (%). p value: χ2 analysis for all genotypes. Y allele frequency is 0.0494, 95% CI 0.047 to 0.0548; D allele frequency is 0.181, 95% CI 0.172 to 0.190. Ethnic group was self reported. *Genotype frequencies for C282Y and H63D variants were each in Hardy-Weinberg equilibrium; however, increased frequency of double heterozygotes (HD/CY) was observed owing to partial linkage disequilibrium (p<0.001) between these variants. | ||||||
| HH/CC | 4195 (59.61) | 4173 (59.30) | 0.6 | |||
| HD/CC | 1952 (27.74) | 1962 (27.90) | 0.76 | |||
| HH/CY | 491 (6.97) | 531 (7.54) | 0.07 | |||
| DD/CC | 215 (3.05) | 230 (3.25) | 0.35 | |||
| HD/CY | 166 (2.36) | 125 (1.77) | <0.001* | |||
| HH/YY | 19 (0.27) | 17 (0.24) | 0.61 | |||