Sex ratio in hereditary breast and ovarian cancer families
| Families | Individuals | Tested mutation carriers | Obligate mutation carriers | Total offspring | Female offspring | *p Value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| *Compared with BRCA1 mutation carriers. | ||||||||||||||
| BRCA1 | 180 | 475 | 453 | 22 | 795 | 458 (57.6%) | ||||||||
| BRCA2 | 99 | 173 | 172 | 1 | 268 | 145 (54.1%) | 0.32 | |||||||
| All tested negative | 389 | 431 | – | – | 556 | 319 (57.4%) | 0.93 | |||||||
| Affected, tested negative | 329 | 355 | – | – | 496 | 288 (58.1%) | 0.87 | |||||||
| Untested (affected, untested) | 608 | 1315 | – | – | 1459 | 862 (59.1%) | 0.50 | |||||||