Expression of STRA13, CA IX, and HIF-α1 in human tumours
| No of positive cases/total No of cases studied | No of positive cases (%) associated with hypoxia (necrosis) | |||||
|---|---|---|---|---|---|---|
| STRA13* (nuclear) | CAIX | HIF-α1* (nuclear) | STRA13* (nuclear) | CAIX | HIF-α1* (nuclear) | |
| *The positive staining is limited to nuclear reactivity. | ||||||
| Ca, carcinoma; LMP, low malignancy potential. | ||||||
| Cervical carcinomas | ||||||
| Squamous cell Ca | 4/12 | 10/12 | 10/12 | 1 (8) | 10 (83) | 10 (83) |
| Adenocarcinoma | 4/4 | 4/4 | 0/4 | 0 | 0 | 0 |
| Endometrial adenocarcinoma | 3/3 | 2/3 | 3/3 | 0 | 0 | 0 |
| Ovary | ||||||
| Adenocarcinoma | 10/14 | 9/14 | 9/14 | 0 | 4 (29) | 4 (29) |
| Mucinous tumours of LMP | 4/4 | 4/4 | 1/4 | 0 | 0 | 0 |
| Breast | ||||||
| Ductal Ca | 5/5 | 3/5 | 3/5 | 0 | 3 (60) | 3 (60) |
| Lobular Ca | 4/4 | 0/4 | 0/4 | 0 | 0 | 0 |
| Colon | ||||||
| Adenocarcinoma | 3/17 | 17/17 | 3/17 | 0 | 5 (29) | 0 |
| Adenoma | 0/3 | 3/3 | 0/3 | 0 | 0 | 0 |
| Lung | ||||||
| Squamous cell Ca | 1/3 | 3/3 | 3/3 | 1 (33) | 3 (100) | 3 (100) |
| Adenocarcinoma | 5/6 | 3/6 | 4/6 | 0 | 0 | 0 |
| Kidney/urinary tract | ||||||
| Renal cell Ca (clear cell) | 6/10 | 9/10 | 6/10 | 0 | 0 | 0 |
| Transitional cell Ca | 4/4 | 4/4 | 4/4 | 0 | 0 | 0 |
| Glioblastoma multiforme | 4/4 | 4/4 | 1/4 | 0 | 4 (100) | 1 (25) |
| Mesothelioma | 1/2 | 2/2 | 0/2 | 0 | 0 | 0 |