Age dependent cause specific cumulative risks and 95% confidence intervals for carriers of mutations at either the hMLH1 or the hMSH2 locus
| Age (years) | CRC (male) | CRC (female) | EC (female) | CRC+EC (female) | ||||
|---|---|---|---|---|---|---|---|---|
| Risk | 95% CI | Risk | 95% CI | Risk | 95% CI | Risk | 95% CI | |
| 30 | 0.49 | (0.13 to 1.8) | 0.63 | (0.14 to 2.8) | 0.04 | (0.01 to 0.13) | 0.67 | (0.15 to 2.9) |
| 40 | 2.3 | (0.90 to 5.7) | 2.5 | (1.0 to 6.5) | 0.48 | (0.15 to 1.5) | 3 | (1.3 to 7.0) |
| 50 | 8.9 | (3.9 to 19.9) | 9 | (3.9 to 19.9) | 3.7 | (1.1 to 11.3) | 12.3 | (6.3 to 23.3) |
| 60 | 19.8 | (9.0 to 40.5) | 17.6 | (8.0 to 36.2) | 16.6 | (5.5 to 44.1) | 31.3 | (16.8 to 53.5) |
| 70 | 26.7 | (12.6 to 51.0) | 22.4 | (10.6 to 43.8) | 31.5 | (11.1 to 70.3) | 46.9 | (25.1 to 75.1) |
| 80 | 28.5 | (13.7 to 53.4) | 23.7 | (11.3 to 45.5) | 45.6 | (17.3 to 85.8) | 58.5 | (30.9 to 87.6) |
| MC (male) | MC (female) | CRC+EC+MC (male) | CRC+EC+MC (female) | |||||
|---|---|---|---|---|---|---|---|---|
| It was assumed that no competing risks took effect. | ||||||||
| CRC, colorectal carcinoma; EC, endometrial carcinoma; MC, minor HNPCC cancer site. | ||||||||
| 30 | 0.064 | (0.023 to 0.17) | 0.36 | (0.13 to 0.97) | 0.53 | (0.16 to 1.8) | 1 | (0.37 to 2.7) |
| 40 | 0.37 | (0.14 to 0.98) | 1 | (0.38 to 2.7) | 2.6 | (1.1 to 6.0) | 3.9 | (2.0 to 7.6) |
| 50 | 1.6 | (0.61 to 4.4) | 2.8 | (1.0 to 7.5) | 10 | (4.7 to 21.0) | 15 | (8.2 to 25.0) |
| 60 | 6 | (2.3 to 15.0) | 6.8 | (2.6 to 17.0) | 24 | (12.0 to 44.0) | 36 | (21.0 to 56.0) |
| 70 | 16 | (6.4 to 38.0) | 13 | (5.2 to 32.0) | 38 | (21.0 to 60.0) | 54 | (32.0 to 78.0) |
| 80 | 33 | (14.0 to 66.0) | 22 | (8.9 to 50.0) | 51 | (30.0 to 76.0) | 67 | (42.0 to 90.0) |