Cause specific hazards relative to the population and absolute cause specific hazards of carriers of mutations at either the hMLH1 or the hMSH2 locus
| Age (years) | Relative risk* | Absolute risk (%)* | |||||
|---|---|---|---|---|---|---|---|
| The logarithms of cause specific relative hazards for colorectal carcinoma (CRC) were assumed to form a quadratic polynomial, which was the same for both sexes. The relative cause specific hazards for endometrial cancer (EC) and minor HNPCC cancer site (MC) were assumed to be constant. | |||||||
| Hazard rates are given as percentages, as they correspond approximately to age dependent incidence rates. | |||||||
| *95% confidence intervals are given in brackets. | |||||||
| CRC (male) | 30 | 25.6 | (15.2 to 43.0) | 0.073 | (0.044 to 0.12) | ||
| 40 | 33 | (21.4 to 51.0) | 0.33 | (0.21 to 0.51) | |||
| 50 | 22.7 | (14.5 to 35.4) | 1.1 | (0.70 to 1.7) | |||
| 60 | 8.3 | (5.3 to 12.9) | 1.3 | (0.82 to 2.0) | |||
| 70 | 1.6 | (0.92 to 2.8) | 0.54 | (0.31 to 0.95) | |||
| 80 | 0.17 | (0.064 to 0.44) | 0.081 | (0.031 to 0.21) | |||
| CRC (female) | 30 | 25.6 | (15.2 to 43.1) | 0.068 | (0.040 to 0.11) | ||
| 40 | 33 | (21.4 to 51.0) | 0.38 | (0.25 to 0.59) | |||
| 50 | 22.7 | (14.5 to 35.4) | 0.94 | (0.60 to 1.5) | |||
| 60 | 8.3 | (5.3 to 12.9) | 0.91 | (0.59 to 1.4) | |||
| 70 | 1.6 | (0.92 to 2.8) | 0.34 | (0.20 to 0.60) | |||
| 80 | 0.17 | (0.064 to 0.44) | 0.058 | (0.022 to 0.15) | |||
| EC | 30 | 29.1 | (16.5 to 51.1) | 0.009 | (0.0051 to 0.016) | ||
| 40 | 29.1 | (16.5 to 51.1) | 0.096 | (0.055 to 0.17) | |||
| 50 | 29.1 | (16.5 to 51.1) | 0.72 | (0.41 to 1.3) | |||
| 60 | 29.1 | (16.5 to 51.1) | 1.9 | (1.0 to 3.3) | |||
| 70 | 29.1 | (16.5 to 51.1) | 2 | (1.1 to 3.5) | |||
| 80 | 29.1 | (16.5 to 51.1) | 2.4 | (1.4 to 4.3) | |||
| MC (male) | 30 | 5.87 | (3.62 to 9.5) | 0.011 | (0.0068 to 0.018) | ||
| 40 | 5.87 | (3.62 to 9.5) | 0.052 | (0.032 to 0.084) | |||
| 50 | 5.87 | (3.62 to 9.5) | 0.24 | (0.15 to 0.38) | |||
| 60 | 5.87 | (3.62 to 9.5) | 0.68 | (0.42 to 1.1) | |||
| 70 | 5.87 | (3.62 to 9.5) | 1.7 | (1.0 to 2.7) | |||
| 80 | 5.87 | (3.62 to 9.5) | 2.5 | (1.5 to 4.0) | |||
| MC (female) | 30 | 5.87 | (3.62 to 9.5) | 0.034 | (0.021 to 0.056) | ||
| 40 | 5.87 | (3.62 to 9.5) | 0.1 | (0.064 to 0.17) | |||
| 50 | 5.87 | (3.62 to 9.5) | 0.27 | (0.17 to 0.44) | |||
| 60 | 5.87 | (3.62 to 9.5) | 0.54 | (0.34 to 0.88) | |||
| 70 | 5.87 | (3.62 to 9.5) | 0.91 | (0.56 to 1.58) | |||
| 80 | 5.87 | (3.62 to 9.5) | 1.2 | (0.73 to 1.90) | |||