Table 3

‚ÄÉCause specific hazards relative to the population and absolute cause specific hazards of carriers of mutations at either the hMLH1 or the hMSH2 locus

Age (years)Relative risk*Absolute risk (%)*
The logarithms of cause specific relative hazards for colorectal carcinoma (CRC) were assumed to form a quadratic polynomial, which was the same for both sexes. The relative cause specific hazards for endometrial cancer (EC) and minor HNPCC cancer site (MC) were assumed to be constant.
Hazard rates are given as percentages, as they correspond approximately to age dependent incidence rates.
*95% confidence intervals are given in brackets.
CRC (male)3025.6(15.2 to 43.0)0.073(0.044 to 0.12)
4033(21.4 to 51.0)0.33(0.21 to 0.51)
5022.7(14.5 to 35.4)1.1(0.70 to 1.7)
608.3(5.3 to 12.9)1.3(0.82 to 2.0)
701.6(0.92 to 2.8)0.54(0.31 to 0.95)
800.17(0.064 to 0.44)0.081(0.031 to 0.21)
CRC (female)3025.6(15.2 to 43.1)0.068(0.040 to 0.11)
4033(21.4 to 51.0)0.38(0.25 to 0.59)
5022.7(14.5 to 35.4)0.94(0.60 to 1.5)
608.3(5.3 to 12.9)0.91(0.59 to 1.4)
701.6(0.92 to 2.8)0.34(0.20 to 0.60)
800.17(0.064 to 0.44)0.058(0.022 to 0.15)
EC3029.1(16.5 to 51.1)0.009(0.0051 to 0.016)
4029.1(16.5 to 51.1)0.096(0.055 to 0.17)
5029.1(16.5 to 51.1)0.72(0.41 to 1.3)
6029.1(16.5 to 51.1)1.9(1.0 to 3.3)
7029.1(16.5 to 51.1)2(1.1 to 3.5)
8029.1(16.5 to 51.1)2.4(1.4 to 4.3)
MC (male)305.87(3.62 to 9.5)0.011(0.0068 to 0.018)
405.87(3.62 to 9.5)0.052(0.032 to 0.084)
505.87(3.62 to 9.5)0.24(0.15 to 0.38)
605.87(3.62 to 9.5)0.68(0.42 to 1.1)
705.87(3.62 to 9.5)1.7(1.0 to 2.7)
805.87(3.62 to 9.5)2.5(1.5 to 4.0)
MC (female)305.87(3.62 to 9.5)0.034(0.021 to 0.056)
405.87(3.62 to 9.5)0.1(0.064 to 0.17)
505.87(3.62 to 9.5)0.27(0.17 to 0.44)
605.87(3.62 to 9.5)0.54(0.34 to 0.88)
705.87(3.62 to 9.5)0.91(0.56 to 1.58)
805.87(3.62 to 9.5)1.2(0.73 to 1.90)