Number of pedigrees | 39 | | | 45 | |
Subjects in the largest pedigree | 108 | | | 70 | |
Generations in the deepest pedigree | 6 | | | 5 | |
Amsterdam criteria I (% of total) | 23 | (59%) | | 32 | (71%) |
Amsterdam criteria II (% of total) | 29 | (74%) | | 40 | (89%) |
Mean size of pedigrees (median) | 27.9 | (24) | | 29 | (25) |
Number of subjects with phenotype information | 1088 | | | 1304 | |
| | | | | |
Non-diseased subjects | | | | | |
Number of subjects (% of total) | 846 | (77.8%) | | 1028 | (78.8%) |
Genotyped (% of non-diseased) | 319 | (37.7%) | | 363 | (35.3%) |
Mutation carriers (% of genotyped) | 156 | (48.9%) | | 149 | (41.0%) |
| | | | | |
Diseased subjects (CRC, EC, MC) | | | | | |
Number of subjects (% of total) | 242 | (22.2%) | | 276 | (21.2%) |
CRC (% of diseased) | 202 | (83.5%) | | 207 | (75.0%) |
EC (% of diseased) | 27 | (11.2%) | | 36 | (13.0%) |
MC (% of diseased) | 13 | (5.4%) | | 33 | (12.0%) |
Genotyped (% of diseased) | 45 | (18.6%) | | 51 | (18.5%) |
Mutation carriers (% of genotyped) | 44 | (97.8%) | | 48 | (94.1%) |
CRC (% of mutation carriers) | 37 | (84.1%) | | 32 | (66.7%) |
EC (% of mutation carriers) | 4 | (11.4%) | | 11 | (22.9%) |
MC (% of mutation carriers) | 2 | (4.5%) | | 5 | (10.4%) |
| | | | | |
CRC before EC or MC | 9 | | | 17 | |
EC before CRC or MC | 13 | | | 14 | |
Mean age at first cancer | | | | | |
CRC men | 43.4 | | | 45.5 | |
CRC women | 42.3 | | | 43.4 | |
EC | 45.7 | | | 43.3 | |
MC | 50.1 | | | 48.6 | |