Table 3

 Association of the MC4R V103I G/A genotype (compared with the wildtype G/G) with BMI as continuous variable via linear regression and with being above average weight (BMI ⩾ age, sex, and survey specific median BMI) via logistic regression

StudyParameterParameter estimate
All†Men‡Women‡
Results are the beta estimate (linear regression), or the odds ratio estimate (logistic regression), with 95% confidence interval and p values in parentheses. *The one subject from S4 with A/A genotype is collapsed into the G/A genotype group; †full model: adjusted for study, sex, age groups assuming a trend per group and an additional change in the BMI–age group relationship for women; ‡sex specific model, adjusted for study, age groups assuming a trend per group. The main results (S3+S4 together) are bold.
Unit change in BMI (slope) in kg/m2
    S3+S4 (n = 7937)G/A* genotype v G/G −0.52 (−1.03 to −0.02) (p = 0.043) −0.36 (−0.95 to 0.23) (p = 0.23)−0.74 (−1.59 to 0.11) (p = 0.09)
Age group all 0.36 (0.31 to 0.41) (p<0.0001) 0.36 (0.32 to 0.40) (p<0.0001)0.65 (0.59 to 0.70) (p<0.0001)
Male 2.21 (1.79 to 2.63) (p<0.0001)
Age group for women 0.29 (0.22 to 0.36) (p<0.0001)
S4 study effect 0.28 (0.09 to 0.48) (p = 0.003) 0.20 (−0.03 to 0.43) (p = 0.10)0.37 (0.07 to 0.67) (p = 0.02)
    S3 (n = 4071)G/A genotype v G/G−0.61 (−1.29 to 0.06) (p = 0.08)−0.73 (−1.49 to 0.02) (p = 0.06)−0.45 (−1.64 to 0.75) (p = 0.46)
Age group all0.36 (0.29 to 0.42) (p<0.0001)0.36 (0.30 to 0.41) (p<0.0001)0.68 (0.60 to 0.75) (p<0.0001)
Male2.47 (1.91 to 3.04) (p<0.0001)
Age group for women0.32 (0.23 to 0.42) (p<0.0001)
    S4 (n = 3866)G/A* genotype v G/G−0.44 (−1.20 to 0.32) (p = 0.25)−0.11 (−0.82 to 1.03) (p = 0.82)−1.03 (−0.82 to 1.03) (p = 0.10)
Age group all0.36 (0.29 to 0.44) (p<0.0001)0.36 (0.30 to 0.43) (p<0.0001)0.62 (0.54 to 0.70) (p<0.0001)
Male1.94 (1.31 to 2.56) (p<0.0001)
Age group for women0.26 (0.15 to 0.36) (p<0.0001)
Relative change of odds of being above average weight (OR)
    S3+ S4G/A* genotype v G/G 0.75 (0.59 to 0.95) (p = 0.017) 0.78 (0.57 to 1.08) (p = 0.133)0.71 (0.49 to 1.01) (p = 0.056)
    S3G/A genotype v G/G0.75 (0.54 to 1.04) (p = 0.093)0.71 (0.46 to 1.09) (p = 0.122)0.81 (0.49 to 1.35) p =  (0.418)
    S4G/A* genotype v G/G0.75 (0.53 to 1.05) (p = 0.088)0.88 (0.55 to 1.41) (p = 0.608)0.62 (0.38 to 1.02) (p = 0.062)