Table 1

Associated allele frequencies, linkage disequilibrium, and single locus estimates of the number of generations since the most recent common ancestor

MarkerAssociated allele†θPnPdδĝLabuda corrections*
r = 1.60r = 1.50
Risch et al5 estimated mutation age using generations ĝ  =  1n(δ)/1n(1−θ), where θ is the recombination fraction between the marker and the mutation, Pn and Pd are the frequencies of the associated marker allele on normal and mutation carrying chromosomes, respectively, and linkage disequilibrium between the marker and the mutation is measured by δ = (Pd−Pn)/(1−Pn). Twenty five years per generation was assumed, and r denotes the growth rate per generation.
*Labuda corrections are added to the single locus estimates (ĝ) to obtain unbiased estimates of mutation age under the assumptions of a bifurcating genealogy.
†See Foulkes et al3 for details of allele numbering.
D2S233140.0770.220.490.3513.253.363.61
D2S230640.0450.350.820.727.184.504.93
Rs868542C0.0210.700.68−0.07NA
D2S39120.0110.190.690.6142.407.428.31
Rs1374749A0.00980.520.770.5167.337.758.69
Rs896213G0.00400.380.890.8151.119.6510.89
D2S222730.000390.280.820.76723.0314.6316.67
MSH2*1906G→C 0.00.01.0NANA
CA31390.000880.150.830.80256.7912.8914.65
CA11430.000900.130.820.79256.3312.8414.59
CA22500.00110.540.940.86136.5512.4114.10
D2S12360.0490.480.600.2329.114.324.71