Table 2

 Physician responses to question about penetrance of HNPCC associated mutations, by specialty, practice characteristics, and age

CharacteristicsIn your opinion, what percentage of patients who carry a gene for hereditary non-polyposis colorectal cancer will actually go on to develop colorectal cancer?*
<50 (%)⩾50 (%)Not sure (%)OR†95% CI
*Unadjusted percentages representing physician responses are weighted to the U.S. population of physicians in the selected specialties. Row percentages may not add to 100% due to item nonresponse. The dependent variable in the logistic regression model is understanding that ⩾50% of carriers of HNPCC associated germline mutations develop colorectal cancer (versus <50% or not sure as the referent category). Weighted ORs and 95% CI are adjusted for all variables in the table. HMO, health maintenance organisation.
Medical specialty
    Family/general practice30.09.358.11.0
    Internal medicine32.417.546.71.91.1–3.0
    General surgeons38.–2.4
Cancer genetics services provided in past 12 months
    Did not order colon cancer genetics tests, but did order other cancer genetics tests or referred patients elsewhere for testing or risk assessment37.915.–2.1
    Ordered colon cancer tests but did not refer patients elsewhere40.818.535.20.90.3–2.8
    Both ordered a colon test and referred patients elsewhere67.813.718.50.90.3–3.2
Local facilities for genetic counselling and testing for inherited cancer risk
    Not sure26.311.–1.6
Clear guidelines or strategies are not available for managing patients with inherited cancer susceptibility mutations
    Agreed with statement, somewhat or strongly38.613.847.01.0
    Disagreed, somewhat or strongly30.919.–2.1
    Not sure13.–1.2
Received cancer genetic test advertising
    No or not sure30.912.854.01.0
Academic affiliation
Practice arrangement
    Full or part owner33.810.353.01.0
    Employee of physician practice, HMO, hospital, university, or clinic33.116.948.71.61.0–2.4
Specialties in the practice
    Single specialty33.911.851.91.0
    Multi specialty32.917.648.61.10.7–1.6