The frequency of large genomic rearrangements in BRCA1 and BRCA2 in a large clinic based population previously negative for BRCA1/2 mutations
| Frequency of genomic rearrangements | ||
|---|---|---|
| Family type | BRCA1 | BRCA2 |
| Female breast cancer only | 2/179 (1.1%) | 0/65 |
| Female breast and ovarian cancer | 4/83 (4.8%) | 0/59 |
| Female and male breast cancer | 0/9 | 3/25 (12%) |
| Total | 6/271 (2.2%) | 3/149 (2%) |