Association analyses of three SNPs in LBP-1c/CP/LSF in two independent family samples
| Single locus analyses* | Haplotype analyses† | ||||
|---|---|---|---|---|---|
| rs4438107 | 3′ UTR | Rs10876135 | |||
| FBAT | z score (p) | z score (p) | z score (p) | Allele | z score (p) |
| NIMH (n = 437) | −0.4 (0.7) | 1.9 (0.05) | −2.0 (0.04) | H4 | 2.1 (0.03) |
| CAG (n = 217) | 0.5 (0.6) | 1.1 (0.3) | 1.4 (0.2) | H4 | 1.3 (0.2) |
| Combined (n = 654) | 0 (1) | 2.2 (0.03) | −0.9 (0.4) | H4 | 2.5 (0.01) |
| PDT | χ2 (p) | χ2 (p) | χ2 (p) | ||
|---|---|---|---|---|---|
| *Minor allele frequencies in the NIMH (CAG) sample are: rs4438107 (T) = 0.46 (0.47), 3′UTR (A) = 0.06 (0.07), rs10876135 (T) = 0.08 (0.06). z score for minor allele or denoted haplotype allele (positive values indicate overtransmission to affected individuals). | |||||
| †Haplotype frequencies in the NIMH (CAG) sample are: H1 (C-G-C) = 0.51 (0.48), H2 (T-G-C) = 0.39 (0.43), H3 (T-G-T) = 0.06 (0.04), H4 (C-A-C) = 0.04 (0.04). Association statistics are presented for risk associated haplotype (H4) and 1 df. | |||||
| NIMH (n = 437) | 0.5 (0.5) | 5.1 (0.02) | 2.8 (0.09) | – | – |
| CAG (n = 217) | 1.2 (0.3) | 0.5 (0.5) | 1.5 (0.2) | – | – |
| Combined (n = 654) | 0 (0.9) | 5.5 (0.02) | 2.1 (0.15) | – | – |