Summary of published case-control AD association studies for the 3′ UTR SNP in LBP-1c/CP/LSF
| Study | AD cases | Normal controls | Results | |||
|---|---|---|---|---|---|---|
| Subjects, n(% women) | Onset age,mean (SD) | Subjects, n(% women) | Age,mean (SD) | A allele frequency(AD v CTRL) | OR (95% CI) | |
| Studies are shown in chronological order, with the most recent study listed first. Odds ratios (ORs) and 95% confidence intervals (CI) as reported by authors; some ORs are adjusted for co-variables (like age, gender, and APOE ε4 status) and might thus vary slightly from the crude ORs presented in fig 1, which were used to calculate summary ORs. | ||||||
| Panza et al15 | ||||||
| Italy | 166 (63%) | 69.4 (10.3) | 225 (68%) | 71.3 (10.4) | 0.06 v 0.02 | 2.97 (1.33 to 6.66) |
| Luedecking-Zimmer et al14 | ||||||
| USA | 564 (68%) | 77.3 (6.4) | 523 (66%) | 76.8 (6.3) | 0.05 v 0.07 | 0.65 (0.43 to 0.96) |
| Taylor et al13 | ||||||
| UK | 239 (64%)* | 81.2 (7.8) | 342 (59%)* | 82.1 (3.8) | 0.05 v 0.08 | 0.59 (0.35 to 1.00) |
| Lambert et al12 | ||||||
| All combined | 1139 (64.6%) | 70.5 (6.6) | 1317 (62.5%) | 73.4 (9.2) | 0.04 v 0.07 | 0.58 (0.44 to 0.75) |
| UK | 159 (67%) | 65.7 (11.1) | 205 (51%) | 60.8 (11.3) | 0.04 v 0.09 | 0.46 (0.23 to 0.93) |
| USA | 296 (67%) | 75.7 (0.2) | 462 (67%) | 79.2 (9.3) | 0.06 v 0.07 | 0.87 (0.56 to 1.38) |
| France | 684 (63%) | 69.4 (8.4) | 650 (63%) | 73.2 (8.6) | 0.04 v 0.07 | 0.48 (0.33 to 0.70) |