Table 3

Genotype and allele frequency

	Controls						HUS
	Genotypes				Allele frequency		Genotypes				Allele frequency
	1/1	1/2	2/2	n	1	2	1/1	1/2	2/2	n	1	2	p Value
CFH, complement factor H; HUS, haemolytic-uraemic syndrome; MCP, membrane cofactor protein.
Newcastle cohort
CFH −257C→T	44	43	5	92	71	29	19	36	12	67	55	45	0.003
CFH c.2089A→G	72	25	1	98	87	13	30	38	6	74	66	34	<0.001
CFH c.2881G→T	62	32	2	96	81	19	32	30	7	69	68	32	0.006
MCP c.IVS12+638G→A	41	38	17	96	62	38	18	28	27	73	44	56	0.001
MCP c.2232T→C	36	41	21	98	58	42	17	32	26	75	44	56	0.012

Paris cohort
CFH −257C→T	57	20	7	84	80	20	29	27	21	77	55	45	<0.001
CFH c.2089A→G	58	18	4	80	84	16	42	20	14	76	70	30	<0.001
CFH c.2881G→T	61	18	4	83	84	16	39	20	15	74	66	34	<0.001
MCP −547A→G	30	34	12	76	62	38	18	23	33	74	39	61	<0.001
MCP-261A→G	33	35	12	80	63	37	16	30	31	77	40	60	<0.001
MCP c.IVS8+23T→G	47	23	3	73	80	20	27	29	21	77	54	46	<0.001
MCP c.IVS9-78G→A	34	35	9	78	66	34	18	29	29	76	42	58	<0.001
MCP c.2232T→C	29	32	9	70	64	36	18	30	29	77	43	57	<0.001