Table 4

 Association of common MAPT haplotypes with progressive supranuclear palsy and corticobasal degeneration

htSNP haplotypesUK PSPUS PSPUS CBD
IDrs1467967rs242557rs3785883rs2471738del-In9rs7521Frequency (%)Association (LRT)Frequency (%)Association (LRT)Frequency (%)Association (LRT)
ControlPSPp (p corrected)ControlPSPp (p corrected)ControlCBDp (p corrected)
The above analysis was based on the output of all haplotypes (>90%), but only those with a frequency >2% were tested for association through the likelihood ratio test (LRT). After adjustment of p values, in parentheses, for correction of multiple testing, only haplotypes A and C in both PSP studies remain significant. No haplotype is significantly associated with CBD after correction for multiple testing.
CBD, corticobasal degeneration; PSP, progressive supranuclear palsy.
A AGGCH2G20.76.3 1.46ex-5 (2.77ex-4) 22.06.3 9.55ex-9 (2.01ex-7) 22.08.20.020 (0.367)
B GGGCH1A16.513.90.378 (1.000)12.215.80.562 (1.000)12.215.40.914 (1.000)
C AAGTH1G11.324.3 0.001 (0.022) 7.824.0 6.42ex-9 (1.35ex-7) 7.817.70.066 (1.000)
D AAGCH1A8.93.70.110 (1.000)4.07.90.077 (1.000)4.07.50.489 (1.000)
E AGGCH1A6.48.40.949 (1.000)15.76.50.014 (0.294)15.74.60.148 (1.000)
F GGACH1A4.01.00.291 (1.000)1.40.01.44.60.588 (1.000)
G GAACH1A3.95.10.691 (1.000)2.63.50.937 (1.000)2.63.40.834 (1.000)
H AGACH1A2.66.50.010 (0.173)0.03.80.404 (1.000)0.00.0
I GAGCH1A2.63.80.960 (1.000)4.45.20.376 (1.000)4.43.30.610 (1.000)
J AGGCH1G2.40.00.033 (0.621)0.03.00.055 (1.000)0.03.40.237 (1.000)
K AAACH1G2.20.90.378 (1.000)0.00.00.00.0
L AGACH1G2.24.10.496 (1.000)3.83.40.338 (1.000)3.80.00.759 (1.000)
M GAGCH1G2.02.60.744 (1.000)3.53.40.930 (1.000)3.55.00.319 (1.000)
N GGACH1G0.93.70.331 (1.000)4.30.60.005 (0.105)4.30.00.018 (0.322)
O AAACH1A0.03.60.070 (1.000)3.41.30.350 (1.000)3.45.00.386 (1.000)
P GGGTH1G1.23.40.509 (1.000)0.41.40.628 (1.000)0.40.0
Q AAGTH1A0.72.80.040 (0.760)0.01.60.003 (0.073)0.01.2
R AGGTH1G0.72.70.114 (1.000)2.41.60.386 (1.000)2.41.50.493 (1.000)
S GGGCH1G1.42.40.599 (1.000)2.62.00.920 (1.000)2.60.00.621 (1.000)
T AGATH1G0.30.01.10.01.17.00.713 (1.000)
U AAGCH1G1.10.01.11.70.270 (1.000)1.13.50.170 (1.000)
v GGATH1G1.30.01.91.00.207 (1.000)1.92.80.699 (1.000)
w GGGCH2G0.00.00.00.00.02.90.326 (1.000)
x GAATH1G0.00.02.70.50.205 (1.000)2.700.174 (1.000)