Table 2

BRCA2 sequence variants

Case no.	Variant		Age (years)		Eth*		Family history†
Case no.	Variant		Age (years)		Eth*		FB		MB		O
*Eth., ethnicity; A J, Ashkenazi Jewish; C, non-Jewish white; AA, African American; H, Hispanic; A, Asian. †Number of first, second, or third degree relatives with female breast (FB), male breast (MB), or ovarian (O) cancers.
Deleterious mutations
50	6174delT	70		J		0		0		0
148	6174delT	54		J		0		0		0
208	6174delT	41		J		0		0		0
307	9132delC	45		W		2		0		0
383	6174delT	45		J		2		1		0
461	6174delT	41		J		3		0		1
Variants of uncertain significance
43	D1420Y/10323delCins11	70		W		0		0		0
91	2166C→T	53		W		1		0		0
111	IVS9–90A→G	48		W		0		0		0
116	S1172L	58		W		0		0		0
149	D1420Y	61		W		2		0		0
219	I2944F	71		AA		1		0		0
246	10338G→A	61		W		3		0		0
267	T3013I	48		W		2		0		0
307	K2950N	45		W		2		0		0
331	IVS15–114delAGT	79		J		0		0		0
386	I2944F	45		H		0		0		0
475	I2944F	58		AA		0		0		0
482	10338G→A	67		W		0		0		0
516	IVS24–16T→C	38		A		0		0		0
517	V3091S	30		W		0		0		0