Table 6

 Potential function domains found in candidates with amino acid alterations caused by single nucleotide polymorphisms: four kinds of diseases

CategoryQTLChrSNP IDGene nameDomain description
QTL  =  quantitative trait loci found in different category; Chr  =  mouse chromosome; SNP ID  =  specific identification number for the SNP from Celera discovery system; Gene name  =  name as in Celera’s annotation; Domain description  =  description as in NCBI Conserved Domain Database.
Ali1/Ali2/Ali 3, acute lung injury quantitative trait loci; Bis1, -carboline induced seizure quantitative trait locus; Exq1, exploratory and excitability quantitative trait locus; MLT1/MLT2/MLT3, mouse lung tumour quantitative trait loci.
Lung tumourMLT14mCV23761092Cdh17KOG4289, cadherin EGF LAG seven-pass G-type receptor
mCV23250954Gpr63KOG4220, muscarinic acetylcholine receptor
MLT26mCV23322871LOC272322KOG3561, aryl-hydrocarbon receptor nuclear translocator
mCV23327408Mrps35KOG3933, mitochondrial ribosomal protein S28
MLT38mCV22993688ADAM29KOG3607, meltrins, fertilins, and related Zn dependent metalloproteinases of the ADAMs family
Acute lung injuryAli111mCV24258169Rad51l3KOG1433, DNA repair protein RAD51/RHP55
mCV22737741MpoKOG2408, peroxidase/oxygenase
mCV24690994AkapKOG2279, kinase anchor protein AKAP149, contains KH and Tudor RNA binding domains
mCV23174311Map3k14KOG0198, MEKK and related serine/threonine protein kinases
Ali213mCV23280804Fgfr4KOG0200, fibroblast/platelet derived growth factor receptor and related receptor tyrosine kinases
mCV22736530Gprk6KOG0986, G protein coupled receptor kinase
Ali317mCV22724951XdhXanthine dehydrogenase, iron-sulphur cluster and FAD-binding subunit A
TrypanosomiasisTir117mCV24105832DaxxDaxx family
mCV24297661Notch4KOG4289, cadherin EGF LAG seven-pass G-type receptor
Tir31mCV24438398Ddr2KOG1094, discoidin domain receptor DDR1
mCV24401565Cd84T cell surface antigen CD2 protein
SeizureExq110mCV23280479Lta4hKOG1047, bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H
mCV25027371IltifInterleukin 10
Bis14mCV24214187Cnr27 Transmembrane receptor (rhodopsin family).
mCV25390842C1qbComplement component C1q domain.
mCV25359925Hspg2KOG3513, neural cell adhesion molecule L1
mCV24058160Kif17KOG0242, kinesin-like protein