Disease loci | QTLs | Total SNP | Filtered SNP | Genes (F) | Confirmed SNP | Genes |
---|---|---|---|---|---|---|
Criteria for filtered SNPs:(1) A/J and C57BL/6J were polymorphic for the SNP;(2) SNPs appeared in the coding region, the 5′ regulatory region, or the 3′ untranslated region;(3) SNPs appeared in known genes;(4) intronic, intergenic, and silent SNPs were excluded. | ||||||
Total SNP = all SNPs found in the region; filtered SNP = SNP number meeting the criteria described in the note; Genes (F) = the number of gene holding filtered SNP; Confirmed SNP = the number of SNP that have been confirmed; Genes = the number of genes holding the confirmed SNP. | ||||||
Ali, acute lung injury locus; Bis, -carboline induced seizure locus; Exq, exploratory and excitability locus; MLT, mouse lung tumour; QTL, quantitative trait loci; SNP, single nucleotide polymorphism; Tir, trypanosomiasis resistance locus. | ||||||
Lung cancer | MLT1 | 25 692 | 26 | 17 | 9 | 9 |
MLT2 | 2477 | 10 | 7 | 3 | 3 | |
MLT3 | 10 245 | 4 | 4 | 1 | 1 | |
Total | 38 414 | 40 | 28 | 13 | 13 | |
Acute lung injury | Ali1 | 36 092 | 95 | 45 | 15 | 13 |
Ali2 | 45 745 | 57 | 29 | 4 | 4 | |
Ali3 | 22 812 | 13 | 8 | 3 | 3 | |
Ali4 | 22 102 | 13 | 6 | 2 | 2 | |
Total | 126 751 | 178 | 88 | 24 | 22 | |
Trypanosomiasis resistance loci | Tir1 | 29 902 | 38 | 24 | 21 | 16 |
Tir2 | 32 479 | 4 | 3 | 3 | 2 | |
Tir3 | 82 246 | 41 | 22 | 8 | 8 | |
Total | 144 627 | 83 | 49 | 32 | 26 | |
Seizures | Exq1 | 25 927 | 6 | 4 | 4 | 4 |
Bis1 | 30 153 | 19 | 11 | 15 | 10 | |
Bis4 | 34 502 | 8 | 8 | 2 | 2 | |
Total | 90 582 | 33 | 23 | 21 | 16 |