Table 1

Allelic frequencies for the RET polymorphic loci in patients with Hirschsprung’s disease (HSCR) and controls

RET sequence variants		Allelic frequency		χ² test with Yates correction
RET sequence variants		HSCR	Controls	χ² test with Yates correction
Statistical analysis of the allelic distribution in both groups.
−1249C→T	Polymorphic T	0.34	0.43	χ² = 3.32, p = 0.08
−1249C→T	Wild type C	0.66	0.57	χ² = 3.32, p = 0.08
−200A→G	Polymorphic G	0.39	0.83	χ² = 86.32, p<0.00000001
−200A→G	Wild type A	0.61	0.17	χ² = 86.32, p<0.00000001
−196C→A	Polymorphic A	0.15	0.44	χ² = 43.7, p<0.00000001
−196C→A	Wild type C	0.85	0.66	χ² = 43.7, p<0.00000001
IVS1+53G→A	Polymorphic A	0.15	0.44	χ² = 43.7, p<0.00000001
IVS1+53G→A	Wild type G	0.85	0.66	χ² = 43.7, p<0.00000001
IVS1+620A→G	Polymorphic G	0.15	0.44	χ² = 43.7, p<0.00000001
IVS1+620A→G	Wild type A	0.85	0.66	χ² = 43.7, p<0.00000001
IVS1+779C→T	Polymorphic T	0.15	0.44	χ² = 43.7, p<0.00000001
IVS1+779C→T	Wild type C	0.85	0.66	χ² = 43.7, p<0.00000001
IVS1+2820C→T	Polymorphic T	0.15	0.44	χ² = 43.7, p<0.00000001
IVS1+2820C→T	Wild type C	0.85	0.66	χ² = 43.7, p<0.00000001
IVS1+2834C→T	Polymorphic T	0.12	0.31	χ² = 18.2, p = 0.0000194
IVS1+2834C→T	Wild type C	0.88	0.69	χ² = 18.2, p = 0.0000194
IVS1+2846T→G	Polymorphic G	0.39	0.83	χ² = 75.2, p<0.00000001
IVS1+2846T→G	Wild type T	0.61	0.17	χ² = 75.2, p<0.00000001
IVS1+3105T→C	Polymorphic C	0.39	0.83	χ² = 75.2, p<0.00000001
IVS1+3105T→C	Wild type T	0.61	0.17	χ² = 75.2, p<0.00000001
IVS1+3991del12	deleted	0.86	0.59	χ² = 35.8, p<0.00000001
IVS1+3991del12	Wild type	0.14	0.41	χ² = 35.8, p<0.00000001
IVS1+6136T→G	Polymorphic G	0.15	0.44	χ² = 43.7, p<0.00000001
IVS1+6136T→G	Wild type T	0.85	0.66	χ² = 43.7, p<0.00000001
IVS1+6174A→G	Polymorphic G	0.15	0.44	χ² = 43.7, p<0.00000001
IVS1+6174A→G	Wild type A	0.85	0.66	χ² = 43.7, p<0.00000001
IVS1+6383–84CC→GG	Polymorphic GG	0.15	0.44	χ² = 43.7, p<0.00000001
IVS1+6383–84CC→GG	Wild type CC	0.85	0.66	χ² = 43.7, p<0.00000001
IVS1+6411A→G	Polymorphic G	0.15	0.44	χ² = 43.7, p<0.00000001
IVS1+6411A→G	Wild type A	0.85	0.66	χ² = 43.7, p<0.00000001
IVS1+7236A→G	Polymorphic G	0.39	0.83	χ² = 75.2, p<0.00000001
IVS1+7236A→G	Wild type A	0.61	0.17	χ² = 75.2, p<0.00000001
IVS1+7436G→A	Polymorphic A	0.39	0.83	χ² = 75.2, p<0.00000001
IVS1+7436G→A	Wild type G	0.61	0.17	χ² = 75.2, p<0.00000001
IVS1+8406del16	deleted	0.86	0.59	χ² = 35.8, p<0.00000001
IVS1+8406del16	Wild type	0.14	0.41	χ² = 35.8, p<0.00000001
IVS1+9202C→T	Polymorphic T	0.39	0.83	χ² = 75.2, p<0.00000001
IVS1+9202C→T	Wild type C	0.61	0.17	χ² = 75.2, p<0.00000001
IVS1+9277T→C	Polymorphic C	0.39	0.83	χ² = 75.2, p<0.00000001
IVS1+9277T→C	Wild type T	0.61	0.17	χ² = 75.2, p<0.00000001
IVS1+9494A→C	Polymorphic C	0.39	0.83	χ² = 75.2, p<0.00000001
IVS1+9494A→C	Wild type A	0.61	0.17	χ² = 75.2, p<0.00000001
IVS1+11260A→T	Polymorphic T	0.39	0.83	χ² = 75.2, p<0.00000001
IVS1+11260A→T	Wild type A	0.61	0.17	χ² = 75.2, p<0.00000001
IVS1+11369C→T	Polymorphic T	0.17	0.44	χ² = 35.8, p<0.00000001
IVS1+11369C→T	Wild type C	0.83	0.66	χ² = 35.8, p<0.00000001
IVS1+11637C→T	Polymorphic T	0.17	0.44	χ² = 35.8, p<0.00000001
IVS1+11637C→T	Wild type C	0.83	0.66	χ² = 35.8, p<0.00000001