Table 1

Two point lod score values for the two families between the disease and the markers of the 22q12.1–q13.1 chromosomal region (OPA5)

		Lod score at h =
		0	0.05	0.10	0.20	0.30
Maximum pairwise lod score >3 at h = 0 were obtained at the D22S275, D22S1176, D22S280, and D22S1158 loci.
D22S1148	Family 1	−∞	0.34	0.48	0.44	0.26
	Family 2	1.18	1.07	0.96	0.73	0.50
	Total	−∞	1.41	1.44	1.17	0.76
D22S275	Family 1	2.41	2.19	1.95	1.44	0.87
	Family 2	0.77	0.70	0.62	0.47	0.32
	Total	3.18	2.89	2.57	1.91	1.19
D22S1176	Family 1	2.71	2.49	2.25	1.74	1.17
	Family 2	1.04	0.95	0.86	0.67	0.46
	Total	3.75	3.44	3.11	2.41	1.63
D22S280	Family 1	2.11	1.91	1.70	1.24	0.72
	Family 2	1.14	1.04	0.93	0.71	0.49
	Total	3.25	2.95	2.63	1.95	1.21
D22S1158	Family 1	2.41	2.19	1.95	1.44	0.87
	Family 2	0.84	0.76	0.68	0.51	0.33
	Total	3.25	2.95	2.63	1.96	1.20
D22S283	Family 1	−∞	0.91	1.00	0.85	0.54
	Family 2	−∞	−2.74	−1.88	−1.06	−0.60
	Total	−∞	−1.84	−0.88	−0.21	−0.06