Table 1

 Clinical differential diagnosis of the skin lesions of pseudoxanthoma elasticum

PXE, pseudoxanthoma elasticum.
PapulesAcquired pseudo-PXE related to haemoglobinopathy
Skin aging (chronological and/or actinic)
Elastoma, Buschke–Ollendorff syndrome
Pseudo-PXE related to salpeter or D-penicillamine
Papular elastorrhexia
Elastosis perforans serpiginosa
Perforating periumbilical PXE
Plaques or redundant skinElastoderma
Cutis laxa
Ehlers–Danlos syndrome (rare)