Association between ESR1 alleles, follow up bone mineral density, and bone loss in postmenopausal women who were not taking hormone replacement therapy
| Characteristic | Number of copies of px haplotype | p Value | ||
|---|---|---|---|---|
| 0 | 1 | 2 | ||
| Values are mean (SEM). | ||||
| Lumbar spine and femoral neck bone mineral density (BMD) values were adjusted for age, body mass index (BMI), and years since menopause; change in BMD values (per cent per year) were adjusted for age, BMI, change in BMI, baseline BMD, and years since menopause. | ||||
| FN, femoral neck; LS, lumbar spine. | ||||
| Number of cases | 212 | 433 | 231 | |
| LS BMD | ||||
| Crude | 0.995 (0.012) | 0.998 (0.008) | 0.967 (0.009) | 0.042 |
| Adjusted | 0.996 (0.011) | 0.997 (0.007) | 0.969 (0.010) | 0.067 |
| FN BMD | ||||
| Crude | 0.842 (0.009) | 0.833 (0.006) | 0.811 (0.007) | 0.014 |
| Adjusted | 0.842 (0.008) | 0.833 (0.005) | 0.814 (0.007) | 0.019 |
| LS BMD change | ||||
| Crude | −1.273 (0.072) | −1.348 (0.052) | −1.382 (0.063) | 0.532 |
| Adjusted | −1.273 (0.068) | −1.356 (0.048) | −1.363 (0.066) | 0.549 |
| FN BMD change | ||||
| Crude | −1.063 (0.069) | −1.231 (0.052) | −1.274 (0.057) | 0.066 |
| Adjusted | −1.051 (0.065) | −1.204 (0.046) | −1.286 (0.062) | 0.030 |