Characteristics of the study subject at baseline and follow up according to menopausal status and use of hormone replacement therapy
| Characteristic | Baseline | Follow up | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Total study population | Total study population | Postmenopausal, no HRT | Postmenopausal HRT users | Pre- and perimenopausal | |||||
| Data are mean (SD). | |||||||||
| *Data for broadband ultrasound attenuation (BUA) and speed of sound (SOS) at the calcaneus were available for 2449 subjects at follow up visit (742 postmenopausal women who were not HRT users, 1465 HRT users, and 242 pre- and perimenopausal women). | |||||||||
| BMD, bone mineral density; BUA, broadband ultrasound attenuation; FN, femoral neck; HRT, hormone replacement therapy; LS, lumbar spine; SOS, speed of sound. | |||||||||
| Number | 3054 | 3054 | 945 (30.9%) | 1802 (59.0%) | 307 (10.1%) | ||||
| Age (years) | 48.5 (2.3) | 54.7 (2.2) | 55.0 (2.2) | 54.8 (2.2) | 53.0 (1.5) | ||||
| Body mass index (kg/m2) | 25.3 (4.4) | 26.5 (4.7) | 26.8 (4.8) | 26.3 (4.6) | 27.0 (5.0) | ||||
| LS BMD (g/cm2) | 1.051 (0.160) | 1.009 (0.168) | 0.990 (0.160) | 1.004 (0.166) | 1.099 (0.175) | ||||
| FN BMD (g/cm2) | 0.880 (0.125) | 0.837 (0.123) | 0.831 (0.120) | 0.832 (0.122) | 0.886 (0.124) | ||||
| Changes in LS BMD (%/year) | – | −0.614 (1.223) | −1.337 (1.048) | −0.322 (1.186) | −0.084 (0.932) | ||||
| Changes in FN BMD (%/year) | – | −0.745 (1.059) | −1.210 (1.016) | −0.558 (1.020) | −0.401 (0.945) | ||||
| Calcaneal BUA (dB/MHz)* | – | 75.5 (17.0) | 73.2 (17.3) | 76.1 (16.8) | 79.0 (16.4) | ||||
| Calcaneal SOS (m/s)* | – | 1553.1 (32.8) | 1548.2 (31.2) | 1554.1 (32.7) | 1561.5 (34.5) | ||||
| Time since menopause (years) | 2.3 (4.5) | 5.7 (6.3) | 6.3 (5.0) | 6.3 (6.9) | – | ||||
| Follow up time (years) | – | 6.2 (0.7) | 6.2 (0.7) | 6.3 (0.8) | 6.1 (0.7) | ||||