Table 1

 Frequency of KRT8 mutations (G62C and Y54H) in patients with chronic liver diseases of different aetiologies and healthy controls

GroupsNumber of individuals studiedG62CY54H
*The group of patients with miscellaneous liver disorders included 21 patients with hepatocellular carcinoma, six patients with cholangiocellular carcinoma, two patients with liver metastases of neuroendocrine tumours, 32 patients with acute liver failure, 14 patients with Budd Chiari’s syndrome, one patient with pregnancy induced cholestasis, 54 patients with metabolic/genetic liver disorders, nine patients with drug-induced liver disease, six patients with biliary cirrhosis, two patients with extrahepatic biliary atresia, and one patient with sarcoidosis. HBV, hepatitis B virus; HCV, hepatitis C virus.
All patients166827 (1.6%)2 (0.1%)
    Chronic HCV infection67213 (1.9%)1 (0.1%)
    Alcoholic liver disease2154 (1.9%)
    Chronic HBV infection2001 (0.5%)1 (0.5%)
    Primary biliary cirrhosis1621 (0.6%)
    Autoimmune hepatitis1044 (3.8%)
    Cryptogenic cirrhosis611 (1.6%)
    Primary sclerosing cholangitis542 (3.7%)
    Non alcoholic fatty liver disease521 (1.9%)
Controls67912 (1.8%)1 (0.1%)