Amsterdam criteria I and II
| Amsterdam criteria I: | |
|---|---|
| 1 | One member diagnosed with colorectal cancer before age 50. |
| 2 | Two affected generations. |
| 3 | Three affected relatives, one of them a first degree relative of the other two. |
| 4 | Familial adenomatous polyposis should be excluded. |
| 5 | Tumours should be verified by pathological examination. |
| Amsterdam criteria II: | |
|---|---|
| 1 | There should be at least three relatives with an HNPCC-associated cancer (colorectal cancer, cancer of the endometrium, small bowel, ureter, or renal pelvis). |
| 2 | One should be a first degree relative of the other two. |
| 3 | At least two successive generations should be affected. |
| 4 | At least one should be diagnosed before age 50. |
| 5 | Familial adenomatous polyposis should be excluded in the colorectal cancer cases. |
| 6 | Tumours should be verified by pathological examination. |