Sample sizes, dropout, missing values, study length, number of waves, compared groups, and accuracy of reporting
| Study | Sample size | Dropout rate | Dropout analysis | Missing value handling | Time span (months) | Waves | Within group | Groups | Between group |
|---|---|---|---|---|---|---|---|---|---|
| N, no; NA, not applicable; Y, yes; ?, unknown. | |||||||||
| Continuous variables, more than two waves | |||||||||
| Codori (1997)60 | 160 | 4% | No differences | Not applicable | 12 | 5 | Y | 2; carriers, non-carriers | Y |
| Meiser (2002)82 | 143 | 20% | No differences | Not applicable | 12 | 4 | Y | 3; carriers, non-carriers, no test | Y |
| Codori (2003)85 | 48 | 27% | Differences found | Not applicable | 55 | 4 | Y | 4; carriers, non-carriers, ditto parents, 3; carrier, non-carrier, mixed families | Y |
| Almqvist (2003)84 | 202 | 48% | Differences found | Not applicable | 60 | 7 | Y | 2; carriers, non-carriers | Y |
| Timman (in press)1 | 302 | 22% | Differences found | Not applicable | 120 | 6 | Y | 4; carriers, non-carriers, partners | Y |
| Wiggins (1992)51 | 135 | 26% | No differences | Imputed | 12 | 4 | Y | 3; carriers, non-carriers, uninformative | Y |
| Tibben (1994)52 | 73 | ? | None | Not mentioned | 6 | 3 | Y | 2; carriers, non-carriers | Y |
| Campodonico (1996)54 | 59 | 75% | None | Excluded | 24 | 3 | Y | 2; carriers, non-carriers | Y |
| Tibben (1997)64 | 86 | 33% | No differences | Not mentioned | 36 | 4 | Y | 4; carriers, non-carriers, partners | Y |
| DudokdeWit (1998)65 | 58 | 36% | Differences found | Mean substitution | 6 | 3 | Y | 2; carriers, non-carriers | Y |
| Aktan-Collan (2001)75 | 271 | 19% | No differences | Excluded | 12 | 4 | Y | 2; carriers, non-carriers | Y |
| Lodder (2002)81 | 102 | 50% | No differences | Imputed | 12 | 4 | Y | 4; carriers, non-carriers, partners | Y |
| Decruyenaere (2003)86 | 57 | 25% | Differences found | Excluded | 60 | 3 | Y | 2; carriers, non-carriers | Y |
| Tercyak (2001)79 | 107? | ? | None | Not mentioned | 2 | 3 | Y | 2; carriers, non-carriers | Y |
| Schwartz (2002)83 | 279 | 20% | Differences found | Not mentioned | 6 | 3 | Y | 3; carriers, non-carriers, uninformative | Y |
| Decruyenaere (1996)56 | 53 | 7% | None | Excluded | 12 | 3 | Y | 2; carriers, non-carriers | Y |
| Dorval (2000)71 | 65 | 9% | No differences | Excluded | 6 | 3 | Y | 3; unaffected LF, BRCA1, affected BRCA1 | Y |
| Friedman (1999)68 | 289 | 31% | Differences found | Excluded | 6 | 3 | Y | 2; non-carriers: increased, decreased risk | Y |
| Oostrom (2003)87 | 65 | 24% | No differences | Not mentioned | 60 | 5 | Y | 2; carriers, non-carriers | Y |
| Horowitz (2001)76 | 79 | 47% | No differences | Not mentioned | 12 | 4 | Y | 2; carriers, non-carriers | Y |
| Brandt (1989)50 | 55 | 75% | None | Not mentioned | 24 | 8 | N | 3; carriers, non-carriers, uninformative | N |
| Lerman (1998)66 | 327 | 18% | Differences found | Excluded | 6 | 3 | Y | 3; carriers, non-carriers, not tested | Y |
| Michie (2001)78 | 19? | 39% | Differences found | Excluded | 18 | 3 | Y | 2; carriers, non-carriers | N |
| Broadstock (2000)70 | 21 | 36% | None | Excluded | 12 | 4 | Y | 1; unaffected at risk | NA |
| Abe (1997)59 | 62 | 5% | None | Not mentioned | 12 | 4 | Y | 3; carriers, non-carriers, affected | N |
| Quaid (1995)53 | 19 | 24% | Differences found | Not mentioned | 12 | 5 | N | 2; carriers, non-carriers | Y |
| Lawson (1996)57 | 135 | ? | None | Not applicable | 12 | 4 | N | 4; carriers, non-carriers, uninformative, not tested | Y |
| Continuous variables, two waves | |||||||||
| Codori (1996)55 | 41 | ? | None | Not applicable | 3 | 2 | Y | 2; carriers, non-carriers | Y |
| Lodder (2001)77 | 78 | 16% | No differences | Not applicable | 1 | 2 | Y | 2; carriers, non-carriers | Y |
| Kirkwood (2002)80 | 43 | ? | None | Not applicable | 44 | 2 | Y | 2; carriers, non-carriers | Y |
| Marteau (1997)62 | 743 | ? | None | Not applicable | 36 | 2 | N | 2; carriers, non-carriers | Y |
| Croyle (1997)61 | 60 | 3% | None | Not applicable | 1 | 2 | N | 2; carriers, non-carriers | Y |
| Decruyenaere (1999)67 | 69 | 27% | None | Not applicable | 12 | 2 | Y | 2; carriers, non-carriers | Y |
| Smith (1999)69 | 212 | ? | None | Not applicable | 1 | 2 | N | 2; carriers, non-carriers | Y |
| Ritvo (2000)73 | 60 | ? | None | Not applicable | 12 | 2 | N | 1; tested women | NA |
| Grosfeld (2000)72 | 25 | 4% | None | Not applicable | 1 | 2 | Y | 3; parents with: carrier child(ren), non-carrier child(ren), both | Y |
| Lerman (1996)58 | 192 | 31% | Differences found | Not applicable | 1 | 2 | Y | 3; carriers, non-carriers, not tested | Y |
| Wood (2000)74 | 35 | ? | None | Not applicable | 1 | 2 | Y | 2; carriers, non-carriers | Y |
| Taylor (1997)63 | 16 | 20% | Description | Not applicable | 108 | 2 | Y | 2; carriers, non-carriers | Y |
| Aktan-Collan (2000)90 | 334 | 19% | Differences found | Excluded | 12 | 3 | Y | 2; carriers, non-carriers | ? |