Tumour history of 26 newly identified patients and their families
| Patient number | Patient’s history | Family history |
|---|---|---|
| The 26 newly identified patients were diagnosed with MTS or suspected of MTS and were included in mutation analysis. | ||
| *A germline mutation was detected in these patients. | ||
| 398* (MTS-24) | Keratoacanthoma (50 years), sebaceous gland hyperplasia (55 years), sebaceous adenoma (57 years), squamous cell carcinoma (57 years), sebaceous gland hyperplasia (61 years), squamous cell carcinoma (66 years), transitional cell carcinoma (ureter) (66 years), carcinoma of jejunum (66 years) | Mother: uterine cancer (46 years), small intestinal cancer (50 years), unknown abdominal cancer (86 years); brother of mother: breast cancer (50 years) |
| 512 | Colon carcinoma (50 years), squamous cell carcinoma (58), bladder cancer (58 years), multiple sebaceous adenomas (58 years) | No HNPCC related tumours |
| 527 | Sebaceous carcinoma (60 years) | Mother: colorectal cancer (40 years), bladder cancer (41 years); brother of mother and his son: gastric cancer (55 years, 39 years) |
| 535* | Small bowel carcinoma (34 years), sebaceous adenoma (47 years) | Mother: colorectal cancer (51 years) |
| 554* (MTS-21) | Cystic sebaceous tumour (58 years) | Sister: endometrial cancer (39 years); father: gastric cancer (<60 years) |
| 555* (MTS-23) | Colon carcinoma (34 years), breast cancer (46 years), uterine cancer (47 years), colon carcinoma (50 years), colon carcinoma (59 years), cystic sebaceous tumour (66 years) | Mother: colon cancer (age unknown); three siblings of mother: gastric cancer (ages unknown); sister of mother: breast cancer (age unknown); cousin: renal cancer (age unknown) |
| 593* | Rectal carcinoma (34 years), sebaceous epithelioma (57 years), sebaceous carcinoma (58 years) | Brother of mother: pancreatic cancer (74 years); grandmother: bladder or liver carcinoma (age unknown) |
| 626 | Multiple sebaceous adenomas (<53 years), sebaceous carcinoma (60 years), colon carcinoma (62 years) | No tumours reported |
| 628* (ST-27) | Colon carcinoma (60 years), sebaceous carcinoma (64 years) | Mother: cervical cancer (age unknown) |
| 631* (MTS-18) | Urothelial carcinoma (56 years), multiple sebaceous tumours and keratoacanthomas (57 years) | Brother: colorectal cancer (age unknown) |
| 655* (ST-29) | Multiple colon carcinomas (age unknown), multiple sebaceous tumours (age unknown), keratoacanthoma (67 years) | Brother: colorectal cancer (age unknown); father: colorectal cancer (age unknown) |
| 667* (ST-28) | Urothelial carcinoma (60 years), bladder cancer (63 years), squamous cell carcinoma (65 years), sebaceous epithelioma (65 years) | Mother: colon carcinoma (78 years); sister of mother: bladder cancer (80 years) |
| 684 (ST-9) | Colon carcinoma (35 years), cystic sebaceous tumour (48 years) | Brother of father: colon carcinoma (72 years) |
| 712 | Colon carcinoma (42 years), breast cancer (49 years), colon carcinoma (54 years), sebaceous carcinoma (57 years) | Sister: colon carcinoma (42 years); mother: colon carcinoma (40 years) |
| 726* | Sebaceous adenoma (60 years), colorectal and gastric cancer (<62 years) | No family history available |
| 727 | Colon carcinoma (50 years), gastric cancer (68 years), sebaceous hyperplasia and sebaceous carcinoma (70 years) | Several family members with colon carcinoma (ages unknown) |
| 747 (ST-31) | Colorectal cancer (44 years), bladder cancer (70 years), sebaceous carcinoma (70 years), sebaceous adenoma (71 years), basal cell carcinomas (>57 years) | Brother: colorectal cancer (age unknown); mother and seven siblings of mother: colorectal cancer or other malignancies (ages unknown) |
| 762* | Endometrial carcinoma (30 years), two colorectal cancers (54 years), desmoid (jejunum) (56 years), sebaceous adenoma (60 years) | Sister: endometrial cancer (41 years), colon carcinoma (51 years); brother of mother: gastric carcinoma (36 years) |
| 765* (ST-63) | Cystic sebaceous tumour (61 years), bladder cancer (64 years), colon carcinoma (68 years) (further history unknown) | Mother: unknown carcinoma of the lower abdomen (67 years) |
| 784 (ST-24) | Sebaceous epithelioma (62 years) | No tumours reported |
| 785 (ST-34) | Sebaceous epithelioma (86 years) | Father: colon carcinoma (age unknown) |
| 787 (ST-10) | Colorectal cancer (72 years), cystic sebaceous tumour (79 years) | No tumours reported |
| 788* (ST-33) | Colon carcinoma (54 years), squamous cell carcinoma, sebaceous epithelioma and two sebaceous adenomas (64 years) | Mother: colon carcinoma (48 years), unknown abdominal carcinoma (53 years); sister of mother: colorectal cancer (48 years); cousin: breast cancer (59 years) |
| 808 (ST-39) | Colorectal cancer (48 years), unknown abdominal cancer (67 years), two sebaceous epitheliomas (78 years) | Mother: unknown abdominal cancer (48 years); brother of mother: lung cancer (age unknown) |
| 810* | Multiple sebaceous hyperplasias, keratoacanthomas, and urothelial cancer (52 years), bladder cancer (53 years), two colon carcinomas (54 years) | Father: colon carcinoma (49 years) |
| 852 (ST-41) | Colon cancer (74 years), sebaceous epithelioma and basal cell carcinoma (81 years), two basal cell carcinomas (age unknown) | No tumours reported |