Table 4

 Hazard ratios of mortality due to CHD and CVD according to ACE I/D genotypes adjusted for age and gender

CHD mortalityCVD mortality
ID (95% CI)DD (95% CI)p (Wald test)ID (95% CI)DD (95% CI)p (Wald test)
The II genotype used as the reference group. CHD, coronary heart disease; CVD, cardiovascular disease; 95% CI, 95% confidence interval.
*Median age = 68.2 years.
Below median age*
    Smokers2.78 (0.33 to 23.10)7.33 (0.92 to 58.65)0.061.91 (0.41 to 9.02)5.19 (1.15 to 23.42)0.03
    Non-smokers0.43 (0.15 to 1.29)0.74 (0.25 to 2.22)0.320.63 (0.25 to 1.60)0.89 (0.33 to 2.36)0.60
    Men0.98 (0.29 to 3.25)2.02 (0.62 to 6.57)0.260.98 (0.37 to 2.61)1.83 (0.69 to 4.88)0.25
    Women0.50 (0.12 to 1.98)1.06 (0.29 to 3.97)0.470.73 (0.21 to 2.59)1.47 (0.43 to 5.03)0.45
Above median age*
    Smokers1.21 (0.69 to 2.13)0.81 (0.41 to 1.61)0.331.14 (0.72 to 1.78)0.99 (0.59 to 1.65)0.73
    Non-smokers0.97 (0.74 to 1.25)0.88 (0.65 to 1.17)0.631.03 (0.83 to 1.27)0.98 (0.77 to 1.23)0.87
    Men1.04 (0.74 to 1.44)0.85 (0.58 to 1.25)0.491.13 (0.85 to 1.51)1.06 (0.77 to 1.45)0.67
    Women0.93 (0.68 to 1.28)0.81 (0.56 to 1.16)0.480.94 (0.74 to 1.19)0.89 (0.69 to 1.16)0.69